Endocrine Abstracts

Introduction: Mixed non-neuroendocrine and neuroendocrine neoplasms (MiNENs) of gastrointestinal tract are rare tumours with characteristic histological features include at least 30% of both neuroendocrine and non-neuroendocrine components of the whole neoplasm. They are usually treated with surgical resection and chemotherapy in advanced disease. However, there is scarcity of data for the use of peptide receptor radionuclide therapy (PRRT) in these tumours.<p class="abste...

Introduction: Metastatic well-differentiated rectal neuroendocrine neoplasms (NENs) are heterogeneous and considered ’immune-cold.’ Standard treatments include somatostatin analogues, peptide receptor radionuclide therapy and chemotherapy. We report a case where a patient responded to third-line immunotherapy, despite the absence of predictive biomarkers.Case Presentation: A 60-year-old man was referred for colonoscopy following bowel cancer sc...