ea0008oc18 | Young Endocrinologist Session | SFE2004
Rao AS
, Kremenevskaja N
, Resch J
, Brabant G
The basic mechanisms underlying thyroid growth and proliferation in thyroid cancer are still incompletely characterized. Lithium inhibits GSK3beta and affects via phosphorylation the degradation of free beta-catenin, a potent transcription factor. Hence, using lithium as a model to modulate the wnt/beta-catenin pathway, we investigated its potential activation in-vitro in neoplastic human thyroid cell lines (FTC133, NPA).Our results show that lithium fun...