Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc5.7 | Thyroid basic | ECE2007

The 1188A/C polymorphism of IL-12 gene in Graves’ disease

Wawrusiewicz-Kurylonek Natalia , Gorska Maria , Mysliwiec Janusz , Kretowski Adam Jacek

Background and aims: Interleukin-12 (IL-12) is a pro inflammatory cytokine, which was suggested to play a key role in the pathogenesis of Th1-cell-mediated autoimmune diseases. The aim of our study was to estimate the association of 1188A/C polymorphism of IL12B gene with the predisposition to Graves’ disease (GD) in Polish population.Materials and methods: The study was performed in the group consisting of 245 individuals with GD sequentially recru...

ea0014p73 | (1) | ECE2007

Circulating pro- and anti-inflammatory cytokines in women with gestational diabetes

Kuzmicki Mariusz , Telejko Beata , Zonenberg Anna , Szamatowicz Jacek , Kretowski Adam , Nikolajuk Agnieszka , Gorska Maria

Gestational diabetes mellitus (GDM) identifies a population of women at high risk of subsequent type 2 diabetes mellitus, representing an early stage in the natural history of the disease. Systemic inflammation is associated with the development of type 2 diabetes but the data concerning pro- and anti-inflammatory cytokines in patients with GDM are limited. The aim of our study was to investigate serum concentrations of interleukin-8 (IL-8), IL-18 and IL-10 in pregnant women w...

ea0035oc4.1 | Diabetes and Obesity 1 | ECE2014

The lower postprandial glucose oxidation in nondiabetic carriers of risk variants of TCF7L2 gene

Adamska Edyta , Kretowski Adam , Goscik Joanna , Waszczeniuk Magdalena , Wawrusiewicz-Kurylonek Natalia , Citko Anna , Ciborowski Michal , Maliszewska Katarzyna , Gorska Maria

Introduction: The transcription factor 7-like 2 gene (TCF7L2) has the strongest effect on the risk of type 2 diabetes but the mechanism for this is not fully understood. Some genetic variants are associated with pancreatic B-cell function and some single nucleotide polymorphisms show a significant correlation with obesity. The aim of the study was to analyze whether TCF7L2 variants may influence body weight and body fat content, as well as postprandial glucose metabolism in no...

ea0037gp.12.03 | Diabetes and obesity – Translational diabetes | ECE2015

Can physical activity modify the impact of the genes on the incidence of type 2 diabetes mellitus?

Szczerbinski Lukasz , Bauer Witold , Goscik Joanna , Wawrusiewicz-Kurylonek Natalia , Paczkowska Magdalena , Niemira Magdalena , Citko Anna , Ciborowski Michal , Maliszewska Katarzyna , Adamska Edyta , Kretowski Adam , Gorska Maria

The exact mechanism of the development of T2DM is still unclear, however, it is known that important role is played by both environmental and genetic factors. In this study we focused on describing the interactions between environmental and genetic factors and answering the question whether physical activity can modify the impact of the genes on the incidence of T2DM. We recruited 921 subjects (median age: 38 years; 49.7% man; mean BMI: 28.1) from the cohort 1000 Polish Longit...

ea0035p392 | Diabetes (epidemiology, pathophysiology) | ECE2014

Resistin mRNA expression in fat and placental tissue of patients with gestational diabetes

Szamatowicz Michal , Wawrusiewicz-Kurylonek Natalia , Kuzmicki Mariusz , Telejko Beata , Wilk Juliusz , Pliszka Justyna , Lipinska Danuta , Szamatowicz Jacek , Kretowski Adam , Gorska Maria

Introduction: Resistin is a cysteine–rich adipokine that was originally described as a molecular link between obesity and insulin resistance. Our previous study showed higher serum resistin levels in patients with gestational diabetes mellitus (GDM) in comparison with healthy pregnant women however conflicting results have been reported by other authors. Therefore in the present study we investigated whether there were significant differences in resistin mRNA expression i...

ea0035p776 | Obesity | ECE2014

Application of LC–MS and CE–MS based metabolomics to study type 2 diabetes development in lean, overweight and obese humans

Ciborowski Michal , Kretowski Adam , Adamska Edyta , Citko Anna , Waszczeniuk Magdalena , Wilk Juliusz , Golonko Anna , Pliszka Justyna , Lipinska Danuta , Goscik Joanna , Rusak Magdalena , Godzien Joanna , Barbas Coral , Gorska Maria

The risk of type 2 diabetes mellitus (T2DM) development is related to BMI, therefore this disease mainly occurs among overweight (OW) and obese (OB) people. However lean (L) individuals may also suffer from T2DM. The evolution of T2DM is a multistep process and starts with insulin resistance (IR), which may evolve into pre-diabetic state i.e.: impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). In up to 70% of patients pre-diabetic state evolves into T2DM. ...

ea0035p977 | Thyroid (non-cancer) | ECE2014

Body mass analysis in patients with Hashimoto thyroiditis

Poplawska-Kita Anna , Telejko Beata , Siewko Katarzyna , Kosciuszko-Zdrodowska Maria , Wawrusewicz-Kurylonek Natalia , Kretowski Adam , Hryiewicka Justyna , Dzieciol Janusz , Bauer Witold , Szelachowska Malgorzata , Gorska Maria

Aim: In Hashimoto thyroiditis (HT) thyroid cells show abnormalities in the intracellular iodine metabolism, associated with the changes in the expression of key proteins involved in the biosynthesis of: thyroid peroxidase (TPO), thyroglobulin (Tg), sodium iodide symporter (NIS) and pendrin. The aim of the present study was to compare the expression of thyroid-specific genes, such as NIS and Tg, as well as pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF&#9...

ea0035p1057 | Thyroid (non-cancer) | ECE2014

Analysis of chosen polymorphisms in FoxP3 gene in children and adolescents with autoimmune thyroid diseases

Bossowski Artur , Borysewicz-Sanczyk Hanna , Wawrusiewicz-Kurylonek Natalia , Szalecki Mieczyslaw , Wikiera Beata , Barg Ewa , Mysliwiec Malgorzata , Kucharska Anna , Bossowska Anna , Gorska Maria , Kretowski Adam

Forkhead box P3 (Foxp3) is an important regulatory factor for the development and function of T regulatory cells (Tregs). Moreover it has been established that deficiency of the Foxp3 gene in Treg cells suppresses their regulatory function leading to the development of autoimmune thyroid diseases (AITDs). The aim of our study was to estimate the association of three polymorphism of FOXP3 gene with the predisposition to GD and HT in children.<p class="abst...

ea0032p360 | Diabetes | ECE2013

TCF7L2 gene polymorphisms may influence insulin sensitivity and leptin levels independently from BMI and body fat content

Kretowski Adam , Adamska Edyta , Wawrusiewicz-Kurylonek Natalia , Citko Anna , Goscik Joanna , Maliszewska Katarzyna , Wilk Juliusz , Waszczeniuk Magdalena , Lipinska Danuta , Pliszka Justyna , Ciborowski Michal , Gorska Maria

Introduction: The genome-wide association studies have recently expanded the number of genetic susceptibility loci for type 2 diabetes and obesity. Transcription factor 7-like 2 (TCF7L2) gene seems to be one of the most predictive identifiable factors promoting T2DM development. It has been suggested that TCF7L2 influences pancreatic β-cell function butthe effect of genetic variants of TCF7L2 on metabolic syndrome development is not well characterized among subje...

ea0035p648 | Female reproduction | ECE2014

Metabolic fingerprint of serum in first trimester of healthy pregnancy permits the prediction of macrosomia

Zbucka-Kretowska Monika , Ciborowski Michal , Bomba-Opon Dorota , Wielgos Miroslaw , Brawura-Biskupski-Samaha Robert , Pierzynski Piotr , Szmitkowski Maciej , Wolczynski Slawomir , Lipinska Danuta , Citko Anna , Bauer Witold , Gorska Maria , Kretowski Adam

Macrosomia is associated with pregnancy complications and is suggested to predict child’s and mother’s health. High birth weight (>4,000 g) has been associated to the risk of several major chronic diseases in future life including diabetes, cardiovascular disease or cancer. Additionally delivery of a large baby carries a risk of perinatal complications. The aim of this study was to obtain serum fingerprints of healthy pregnant women to identify early biomarkers o...