Searchable abstracts of presentations at key conferences in endocrinology

ea0062wc6 | Workshop C: Disorders of the thyroid gland | EU2019

Isolated Thyroxinaemia

Quader Monzoor , Krishnasamy Senthil

A 54 year old male was referred by GP for abnormal TFT. Thyroid function was done routinely. TSH 3.0 (normal 0.5 to 4.5), FT4-25.2. GP repeated the TFT twice, and both of them were similar. There were no clinical features of Thyrotoxicosis. On examination, his heart rate was 78/min regular, wt 79 kg, no thyroid enlargement, no tremor. Cardiovascular examination was unremarkable. He is fit and well gentleman. He does not take any regular medication. No history of taking any oth...

ea0062wc7 | Workshop C: Disorders of the thyroid gland | EU2019

Carbamazepine induced low FT4

Quader Monzoor , Krishnasamy Senthil

This is 66 year old lady was referred by GP for Abnormal TFT. Her TFT was done routinely and showed TSH-2.7, FT4-9.8. Patient did not have symptoms of hypothyroidism, or did not have any weight gain. On examination, thyroid was not enlarged. In view of Low FT4, she was started on Levothyroxine 25 mcg once daily. After taking the medications she felt warm and unsteady and noticed tremour on both hands. The repeat TFT came back as normal. TSH-2.9, FT4-14.2\. In view of pts sympt...

ea0062wd13 | Workshop D: Disorders of the adrenal gland | EU2019

Polyglandular autoimmune syndrome

Quader Monzoor , Krishnasamy Senthil

This was a 26 year old girl was referred for addisons disease. Her initial blood test showed low Na-123 with raised K-6. She complained feeling tired and lethargic for last 2 months. On examination, wt 108 kg, alopecia on the occipital scalp. Obese lady, CVS and respiratory system examination were normal. Her Short Synacthen test showed blunted response. She was immediately started on Hydrocortisone 10-5-5. Furhter bloods showed TSH-18, FT4-5.6, positive Anti TPO Ab, positive ...

ea0062we3 | Workshop E: Disorders of the gonads | EU2019

Erectile dysfunction

Quader Monzoor , Krishnasamy Senthil

This is a 46 year old man who was referred by GP for erectile dysfunction. He is a married with two daughters. His complaint started 1 year back with lethargy and tiredness. He is fit and well. He does not take any regular medication. He is shaving regularly. On examination, wt 80 kg. All the secondary sexual characteristics were present. No Galactorrohoea. Testes size was normal. His total testosterone level was low. Anterior pituitary hormone profile showed very low LH and F...

ea0077p128 | Thyroid | SFEBES2021

A case of Transient Neonatal Thyrotoxicosis born to mother with Graves’ Disease

Musharraf Adeel , Kandaswamy Leelavathy , Krishnasamy Senthil-Kumar

Neonatal autoimmune hyperthyroidism is rare but potentially fatal condition. It occurs in 1-5% of infants born to pregnant mothers with GravesÂ’ disease (GD). We present a case of transient neonatal thyrotoxicosis born to pregnant women with GD and high TSH Receptor antibodies. 42 years pregnant lady was referred to Antenatal Endocrine clinic at Walsall Manor Hospital in 15th week of pregnancy with symptoms of Thyrotoxicosis. She has GD and was taking Propylthio...

ea0077lb33 | Late Breaking | SFEBES2021

Complex management of unilateral post-Covid-19 adrenal haemorrhage during pregnancy

Yousuf Quratulain , Elhassan Yasir S , Arlt Wiebke , Jehanzeb Qazi , Krishnasamy Senthil-Kumar , Ronchi Cristina L

Background: Management of large indeterminate adrenal masses detected during pregnancy is challenging due to the risk of malignancy and the obstetric risks of surgical intervention. The spectrum of endocrine-related complications of Covid-19 is expanding. We present a case that highlights the challenging management of a large adrenal mass during pregnancy and draws attention to a rare complication of Covid-19.Case description: 26 yr-old lady presented wi...

ea0034p93 | Clinical practice/governance and case reports | SFEBES2014

Can a random cortisol predict outcome of short Synacthen test in non-acute patients with low pre-test probability?

Kannan Rajendran Bellan , Krishnasamy Senthil , Nayak Ananth , Jose Biju , Varadhan Laks

Background: Short Synacthen test (SST) is being increasingly used in various clinical conditions, mainly for completion purpose of ruling out adrenocortical insufficiency rather than actively suspecting it (for instance hypothyroidism with tiredness, type 1 diabetes with hypoglycaemia). The aim of our retrospective analysis was to assess if a random cortisol could predict the outcome of SST.Method: Data were collected on all SST done at the endocrine uni...

ea0081rc5.7 | Rapid Communications 5: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2022

How do people with type 2 diabetes compare with type 1 diabetes in their outcomes of diabetes-related ketoacidosis?

Birchenough Amy , Krishnasamy Senthil , Saraf Sanjay , Owen Megan , Rajendran Dineshwaran , Ponniah Gobeka , Yip Wai Nga Alice , Warmington Emily , Hebbar Meghnaa , Sheikh Haaziq

Introduction: Diabetes-related ketoacidosis (DKA) is an acute endocrine emergency requiring immediate diagnosis and management. Common misconception is that DKA is associated with type 1 diabetes only. We explored the proportion of people with type 2 diabetes, and compared the management, complications and outcome of DKA between people with type 1 and type 2 diabetes.Methods: We conducted a retrospective study on people admitted with DKA across six hospi...

ea0081rc10.6 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Differences in prevalence of, and precipitating factors for, diabetes related ketoacidosis in type 1 and type 2 diabetes mellitus

Zhou Dengyi , Sheikh Haaziq , Rajendran Dineshwaran , Soghal Shamanth , Yip Wai Nga Alice , Anilkumar Anjitha , Hebbar Meghnaa , Rengarajan Lakshmi , Krishnasamy Senthil , Narendran Parth

Introduction: Diabetes related ketoacidosis (DKA) is usually associated with type 1 diabetes mellitus (T1DM). However, DKA is increasingly being recognised in type 2 diabetes mellitus (T2DM). We studied the differences in prevalence and precipitating factors of DKA between T1DM and T2DM.Methods: This retrospective study included all DKA episodes from January to November 2021 in six hospitals in the West Midlands, UK. DKA was diagnosed as serum glucose&#8...

ea0090p328 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

How do diabetes-related ketoacidosis outcomes compare between hospitals? Results from a quality improvement project

Hallum Abigail , Narendran Arjun , Dalzell Joseph , Needs Catherine , George Arun , Narendran Parth , De Parijat , Lubina Solomon Alexandra , Krishnasamy Senthil , Raghavan Rajeev , Working Group Dekode

Background: The appropriate and timely management of diabetes-related ketoacidosis (DKA) has important implications for patient outcomes. Despite the availability of national management guidelines to promote standardised care, we do not know if there are differences in DKA outcomes and complications between hospitals.Aim: To assess for differences in DKA outcomes and treatment complications between hospitals.Methods: This retrospec...