Searchable abstracts of presentations at key conferences in endocrinology

ea0056p611 | Steroid metabolism + action | ECE2018

Sex differences in glucocorticoid-induced metabolic disturbances in mice

Kaikaew Kasiphak , Steenbergen Jacobie , Kroon Jan , Meijer Onno C , Grefhorst Aldo , Visser Jenny A

Introduction: Glucocorticoids (GCs) are widely used anti-inflammatory medications that cause many metabolic side effects. Long-term treatment with GCs causes obesity and induces insulin resistance in many metabolic tissues, including adipose tissue and muscle. Factors secreted by adipose tissue, so-called adipokines, including leptin and adiponectin, also regulate the glucose-insulin axis. Obesity increases circulating leptin but decreases adiponectin levels. Despite several s...

ea0063oc12.1 | Endocrine Connections 2 | ECE2019

Weekly shifts in light-dark cycle disrupt circadian clock gene expression in bone and reduce bone turnover

Schilperoort Maaike , Bravenboer Nathalie , Kroon Jan , Lim Joann , Ruyven Leo van , Rensen Patrick , Kooijman Sander , Winter Elizabeth

The past decade, epidemiological studies have associated disturbances of the biological clock, as occurs in shift work, with low bone mineral density and increased fracture risk. As a large part of the working population participates in shift work (e.g. almost 30% of workers in the U.S.), this demonstrates the need for further research on the risk of skeletal disorders associated with circadian disturbances. In this study, we aimed to investigate to what extent rhythmicity exi...