Searchable abstracts of presentations at key conferences in endocrinology

ea0014me6 | (1) | ECE2007

Differential diagnosis of hypercortisolism

Krsek Michal

Diagnosis and differential diagnosis of Cushing’s syndrome belongs to the most difficult ones in clinical endocrinology and is essential for optimal management of this syndrome. Clinical presentation of Cushing’s syndrome and frequency of particular clinical signs with respect to their importance for diagnosis and differential diagnosis of Cushing’s syndrome will be discussed. Subsequently, biochemical tests used for confirmation of Cushing’s syndrome will ...

ea0056mte2 | (1) | ECE2018

Acromegaly: Optimal management after surgery

Krsek Michal

Acromegaly is a rare condition caused by overproduction of growth hormone (GH). Early diagnosis, optimal treatment and follow-up is essential for prognosis of patients with acromegaly. Surgery is first choice treatment of acromegaly. Cure rates range around 80% (63–100%) in GH secreting microadenomas, however only about 50% (40–72) in macroadenomas. If not curable, surgery has to be followed by other treatment modalities to achieve treatment goals that are according ...

ea0035p884 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Register of sellar tumors: RESET: diagnostics and therapy of acromegaly in Czech and Slovak Republics

Hana Vaclav , Svancara Jan , Bandurova Lubomira , Brabec Petr , Cap Jan , Durovcova Viktoria , Dvorakova Eva , Hana Vaclav , Jarkovska Zuzana , Kentos Peter , Klimes Daniel , Krcma Michal , Krsek Michal , Lazurova Ivica , Olsovska Vera , Podoba Jan , Pura Mikulas , Sasikova Michaela , Stary Karel , Strenkova Jana , Siprova Helena , Steno Juraj , Trejbalova Ludmila , Vanuga Peter , Wagnerova Hedviga , Weiss Vladimir , Zeman Dalibor , Dusek Ladislav , Marek Josef

Acromegaly is usually diagnosed after several years of duration. The multimodal therapy – surgery, radiotherpy, pharmacotherapy – is necessary in the majority of patients. Register of sellar tumors (RESET) collecting data of patients from eight tertiary centers in the Czech and Slovak Republics since the year 2000 was established in 2008.Aim of analysis: Evaluation of diagnostics of acromegaly and effectiveness of its treatment in a daily pract...

ea0037ep751 | Pituitary: clinical | ECE2015

Endonasal endoscopic pituitary adenoma resection

Masopust Vaclav , Netuka David , Benes Vladimir , Bradac Ondrej , Marek Josef , Hana Vaclav , Krsek Michal

Introduction: In the past 10 years, endoscopic resection of pituitary adenomas has become an alternative to microsurgical resection with the additional advantage of increasing the patient’s postoperative comfort. This analysis explored whether endoscopic resection can reduce the risk of postoperative neurohypophyseal dysfunction.Material and methods: We rated and compared the need to administer desmopressin during the first four postoperative days a...

ea0032p31 | Adrenal cortex | ECE2013

Reliability of serum versus salivary cortisol in ACTH test

Kosak Mikulas , Hana Vaclav , Hill Martin , Simunkova Katerina , Lacinova Zdena , Krsek Michal , Marek Josef

Introduction: Salivary cortisol measurement, representing free cortisol, seems to be a promissing alternative method to serum cortisol. Besides its use in the diagnostics of hypercortisolism, it could be of help in evaluation of adrenocortical reserve. It might be useful especially in patients on estrogen replacement, which modulates transcortin and hence total cortisol levels.Aims: Compare the reliability of salivary vs. serum cortisol assessment during...

ea0022p595 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Pituitary functions in patients with chronic subdural hematoma

Kosak Mikulas , Masopust Vaclav , Netuka David , Lacinova Zdenka , Krsek Michal , Marek Josef , Hana Vaclav

Certain degree of hypopituitarism has been revealed in a significant number of patients who suffered traumatic brain injuries or subarachnoid hemorrhage. Microhemorrhages, necrosis, tissue infarcts and vasoconstriction are reported as mechanism of hypothalamo-pituitary dysfunction. Assessment of hypothalamo-pituitary endocrine functions in patients with chronic subdural hematomas has not been published yet, although dysfunction of hypothalamo-pituitary unit can be expected (he...

ea0020p491 | Obesity and Metabolism | ECE2009

Regulation of novel metabolic regulator fibroblast growth factor-21 by body adiposity and hypercortisolemia: studies in patients with obesity and Cushing’s syndrome

Durovcova Viktoria , Krsek Michal , Hana Vaclav , Marek Josef , Bartlova Marketa , Kavalkova Petra , Haluzik Martin

Fibroblast growth factor-21 (FGF-21) is a novel regulator of metabolic homeostasis that improved diabetes compensation and dyslipidemia in diabetic mice and monkeys. However, little is known about its regulation in humans. Cushing’s syndrome (CS) is characterized by endogenous hypercortisolism and is often associated with numerous metabolic abnormalities. The objective of this study was to test the hypothesis that CS is associated with altered levels of FGF 21 that may in...

ea0020p574 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Is it possible to avoid hypopituitarism after the irradiation of pituitary adenomas by the Leksell gamma-knife?

Marek Josef , Jezkova Jana , Hana Vaclav , Krsek Michal , Liscak Roman , Vladyka Vilibald

Radiation therapy is used in the treatment of pituitary adenomas, especially in failures of neurosurgery and pharmacotherapy to reduce the size of adenomas and normalize their hypersecretion. Conventional fractionated radiotherapy has achieved good results, but only after a long latency, with considerable postradiation morbidity and with very frequent appearance of hypopituitarism. The focal stereotactic targeting allowed by Leksell gamma-knife (LGK) was supposed to decrease t...

ea0037ep51 | Adrenal cortex | ECE2015

Comparison of 17-OH progesterone response to various dose of tetracosactide

Kosak Mikulas , Duskova Michaela , Simunkova Katerina , Hana Vaclav , Krsek Michal , Jandikova Hana , Pospisilova Hana , Sramkova Monika , Velikova Marta , Starka Luboslav

ACTH test is widely accepted as diagnostic tool in suspicion on peripheral as well as on central hypocorticism. The optimal dose of tetracosactide for determination of hypocorticism is still matter of debate. The 250 μg as a standard dose of tetracosactide has been approved for diagnosis of congenital adrenal hyperplasia (CAH) many years ago. Moreover, current limited availability of tetracosactide and its increased financial cost on the market raised the question whether...

ea0035p913 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Cortisol metabolites response in hypothalamic–pituitary–adrenal axis tests

Simunkova Katerina , Duskova Michaela , Krsek Michal , Hana Vaclav , Hill Martin , Kosak Mikulas , Jandikova Hana , Pospisilova Hana , Starka Luboslav

The aim of the study was a detailed analysis and a comparison of hypothalamic–pituitary–adrenal axis tests and cortisol metabolites analysis during these tests. This procedure might enable to design new diagnosis algorithms of hypocorticalism and normal levels for salivary cortisol estimation for early diagnostic of patients with hypothalamic–pituitary–adrenal axis disorder as well as to give us a possibility to reveal adrenal disorder in patients on estrog...