Searchable abstracts of presentations at key conferences in endocrinology

ea0065p281 | Neuroendocrinology | SFEBES2019

Clinical PhenClinical phenotypes of GNAS gene mutations in Korean Acromegalic Patientsotypes of GNAS gene mutations in Korean acromegalic patients

Ku Cheol Ryong , Jung Hyein , Kim Kyungwon , Kim Daham , Lee Eun Jig

Background: Guanine nucleotide-binding protein, α stimulating (GNAS) gene have been reported to be associated with GH secreting pituitary adenoma. Approximately 40% of patients with acromegaly have GNAS mutation. In this study, we investigated the prevalence of GNAS mutation in Korean acromegalic patients and assessed the correlation with the biochemical or clinical characteristics.Method: We studied acromegalic patients who underwent surgery betwee...

ea0049ep1173 | Male Reproduction | ECE2017

Gonadal status in males with acute coronary syndrome and the extent of coronary artery disease: a comparative cross-sectional analysis

Bednarova Adriana , Koller Tomaš , Kužma Martin , Payer Juraj

Introduction and aims: Association between coronary artery disease (CAD) and male gonadal status has been previously suggested, but still remains inconclusive. Aims of our study in males with recent acute coronary syndrome (ACS) were to evaluate the prevalence of hypogonadism, to compare their gonadal status with non-ACS matched controls and to evaluate gonadal status by the extent of CAD.Subjects and Methods: A cross-sectional retrospective study includ...

ea0037ep787 | Pituitary: clinical | ECE2015

The effect of pregnancy and lactation on prolactinoma

Kim Wonjin , Ku Cheol Ryong , Hong Jae Won , Lee Eun Jig

Prolactinoma predominantly occurred in young women of reproductive age. But there are limited data about the effect of pregnancy and lactation on prolactinoma progression. We evaluated the safety of dopamine agonists including bromocriptine and cabergoline and pregnancy outcome in prolactinoma patients. Patients diagnosed with prolactinoma who experienced pregnancies were included. Sellar MRI and serum prolactin levels were performed before and after pregnancy and lactation. T...

ea0011p591 | Neuroendocrinology and behaviour | ECE2006

Evaluation of cognitive functions by using p300 auditory event related potentials (ERPs) in patients with growth hormone (GH) deficiency and gh excess

Tanriverdi FT , Suer CS , Yapislar HY , Unluhizarci KU , Bayram FB , Kelestimur FK

Objective: Impaired cognitive function has been demonstrated in adults with GH deficiency (GHD) and acromegaly by using different neuropsychological tests. P300 ERP application is a well established neurophysiological approach in the assessment of cognitive function. However the comparison of the P300 ERPs between GHD and GH excess have not been done yet. The present study was designed to investigate the effects of GHD and acromegaly on cognitive function by using P300 ERPs.</...

ea0084ps1-03-23 | Thyroid Cancer CLINICAL 1 | ETA2022

Comparison between minimal and gross ete for risk of recurrence in papillary thyroid carcinoma : a propensity score matching study

Park Joonseon , ku kang il , Kim Kwangsoon , Seong Bae Ja , kim jeongsoo

Background: The presence of extathyroidal extension (ETE) is associated with locoregional recurrence and distant metastases in papillary thyroid carcinoma (PTC). ETE is classified into gross ETE (gETE) and minimal ETE (mETE). The mETE was recently excluded from the T3 category in the TNM staging system. The purpose of this study is to compare the recurrence risk of mETE and gETE in PTC patients through propensity score matching analysis. And a comparison in the same way for pa...

ea0070aep170 | Bone and Calcium | ECE2020

Long term effect on trabecular bone score but not BMD is preserved in GH-deficient adults only when sufficient vitamin D levels are maintained

Kužma Martin , Smaha Juraj , Stojkovičová Daša , Jackuliak Peter , Killinger Zdenko , Payer Juraj

Introduction: Adult growth hormone deficiency (AGHD) is associated with lower bone mass and likely with increased risk of fragility fractures. GH replacement leads to increase in bone mineral density (BMD) and trabecular bone score (TBS). The effect of adequate levels of vitamin D during GH replacement is important to provide effect on TBS.Aim: To assess long–term effectof recombinant GH replacement on BMD and TBS with regards to vitamin D levels d...

ea0056gp111 | Diabetes Translational | ECE2018

Olfactory receptor OR51E1 mediates GLP-1 secretion in enteroendocrine L cells

Ku Cheol Ryong , Han Ye Eon , Kim Daham , Hong Jae Won , Kim Sun Ho , Lee Eun Jig

Few studies have investigated the intracellular signaling pathways mediating the effects of glucagon-like peptide-1 (GLP-1) secretagogues in enteroendocrine L cells. Specific receptors, channels, and intracellular signaling proteins expressed by the L cells have only begun to be characterized. The present study aimed to investigate the role of the olfactory receptor (OR) OR51E1 in GLP-1 secretion. We verified the expression of olfactory marker protein (OMP), an indicator of OR...

ea0056gp194 | Pituitary Basic | ECE2018

Olfactory marker protein regulates prolactin secretion and production by modulating Ca2+ and TRH signaling in lactotrophs

Ku Cheol Ryong , Kang Chan Woo , Kim Daham , Hong Jae Won , Kim Sun Ho , Lee Eun Jig

Olfactory marker protein (OMP) is a marker of olfactory receptor-mediated chemoreception, even outside the olfactory system. Here, we report that OMP expression in the pituitary gland plays a role in basal and thyrotropin-releasing hormone (TRH)-induced prolactin (PRL) production and secretion. We found that OMP was expressed in human and rodent pituitary glands, especially in PRL-secreting lactotrophs. OMP knockdown in GH4 rat pituitary cells increased PRL production and secr...

ea0056p294 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Lobeglitazone, a novel thiazolidinedione, improves hepatic steatosis in diet-induced obese mice

choung Sorim , You Bo Ram , Kim Ji Min , Joung Kyong Hye , Kim Hyun Jin , Ku Bon Jeong

Although non-alcoholic fatty liver disease (NAFLD) patients are rapidly growing, there is not optimal therapy to improve NAFLD. NAFLD is strongly associated with insulin resistance. The peroxisome proliferator-activated receptor (PPAR) activator thiazolidinediones (TZD) is an insulin sensitizer, and have been focused as the drug for NAFLD. However, the TZD remain debate as drug of choice on NAFLD because of its conflicting results on the hepatic steatosis and fibrosis. Lobegli...

ea0056p806 | Pituitary - Clinical | ECE2018

Association between prolactin level and tumor size reduction at 3 months after cabergoline treatment in patients with macroprolactinoma

Kim Daham , Lee Youngki , Park Se Hee , Park Kyeong Hye , Ryong Ku Cheol , Kim Sun Ho , Lee Eun Jig

Objectives: Prolactin (PRL) normalization after 3 months of Cabergoline (CAB) treatment are useful predictors of responsiveness in patients with prolactinoma. However, differences within the PRL normalization cut-off value have not been identified.Methods: We reviewed the medical records of patients with prolactinomas who were treated with CAB as a primary drug at Severance Hospital. We included patients who had a full dataset of pituitary hormone assays...