Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1617 | Thyroid (non-cancer) | ICEECE2012

Subclinical hyperthyroidism (SH) in the elderly: symptoms, depression and quality of life (QoL) and relationship with TSH concentration in a prospective cohort of 110 patients

Goichot B. , Vinzio S. , Kuhn J. , Meyer N. , Wemeau J. , Caron P. , Luca F. , Orgiazzi J.

SH is defined by a decrease of TSH with normal thyroid hormone (TH) concentrations. The clinical picture is not clear, whether these patients may have symptoms or alterations of QoL. It is well known that in overt hyperthyroidism, symptoms may be absent in old patients. In SH, one study in young patients has reported an increased symptom score and a slight decrease of QoL but these results have not been confirmed in middle-aged subjects. We report the initial data of the Pirat...

ea0029oc13.3 | Adrenal Basic | ICEECE2012

Cortisol secretion is dependent on intraadrenal production of ACTH in macronodular bilateral adrenal hyperplasia causing Cushings syndrome

Louiset E. , Duparc C. , Young J. , Boutelet I. , Renouf S. , Bram Z. , Groussin L. , Caron P. , Tabarin A. , Grunenberger F. , Christin-Maitre S. , Kuhn J. , Anouar Y. , Bertherat J. , Lefebvre H.

Illicit expression of membrane receptors for circulating regulatory factors, such as gastric inhibitory polypeptide (GIP), luteinizing hormone (LH) and serotonin (5-HT) receptors, has been well documented in ACTH-independent macronodular adrenal hyperplasias (AIMAHs) causing CushingÂ’s syndrome. In addition, we have observed an abnormal expression of ACTH in some steroidogenic cells in two AIMAH tissues. The aim of the present study was to investigate the role of local pro...