Searchable abstracts of presentations at key conferences in endocrinology

ea0032p565 | Endocrine tumours and neoplasia | ECE2013

Extraordinary effect of ketoconazole in treatment of ACTH-dependent paraneoplastic Cushing syndrome

Bohacikova Andrea , Kulich Michal , Vanuga Peter

Background: Although the excision of ACTH-producing tumors or adrenal tumors is the principal treatment for Cushing syndrome (CS), pharmacologic treatment has a well-established role. Among various medical agents, ketoconazole (KTZ) has inhibitory effect over 17,20 desmolase, 17α-hydroxylase, 11β-hydroxylase, and 16α- and 18-hydroxylase; moreover, it also inhibits ACTH production and cellular growth, partly because of apoptosis induction.C...

ea0022p249 | Clinical case reports and clinical practice | ECE2010

Cushing syndrome in patient with thyroid orbitopathy (case report)

Vanuga Peter , Kulich Michal , Pavai Dusan

Authors present a 35-year-old female with thyroid orbitopathy (EO) associated with Graves disease. After initial antithyroid therapy, thyroidectomy was indicated and performed uneventenfully. Due to persisting severe clinically active EO, thyroablative therapy with 131I was performed three years later, intravenous pulse of methylprednisolone was given and consecutive oral therapy with prednisone initiated. This caused weight gain (from 63 to 80 kg) and iatrogenic Cu...

ea0041ep80 | Adrenal cortex (to include Cushing's) | ECE2016

Cushing syndrome with ectopic secretion of ACTH by a lung carcinoma

Moravcikova Elena , Kulich Michal , Urbankova Helena , Gregova Juliana , Vanuga Peter

Introduction: A form of ACTH-dependent Cushing syndrome is an ectopic production of ACTH. The aetiology can by benign lesion or a malignant non-pituitary tumor, which is more common. The prevalence of endogenous Cushing syndrome is 1 in 26 000. Ectopic ACTH secretion is responsible for 7–15% of the cases. Principal position of the ACTH-producing tumor is in lungs – a bronchial endocrine tumor and small cell lung cancer. Small peripheral bronchial carcinoids can easil...

ea0037ep731 | Pituitary: clinical | ECE2015

Carney complex – a case report

Urbankova Helena , Kulich Michal , Veteskova Elena , Vanuga Peter

Carney complex (CNC) is rare autosomal dominant disorder, which was firstly described as a combination of manifestation of myxomas, spotty skin pigmentation and endocrine overactivity in 1985. This condition affects many organs and varies in clinical manifestation. The presence of at least two clinical signs is considered as pathognomonic with regard to a sporadic form of CNC, and an evidence of at least one sign with simultaneous manifestation of CNC in any of first degree re...

ea0099ep931 | Reproductive and Developmental Endocrinology | ECE2024

Two sides of the same coin: infertile couple

Moravcikova Elena , Urbankova Helena , Vanuga Peter , Kulich Michal

Introduction: Our case is a young couple, both endocrinologically monitored from childhood. Woman with diagnosis of oligomenorrhea – secondary amenorrhea. Man with delayed puberty. After complex endocrinological screening both diagnoses was changed to: woman diagnosed with prolactinoma and man with isolated idiopathic central hypogonadism (IICH). They were trying to concieve for 10 years with no succes.Case: Woman: At 17 years of age diagno...

ea0090ep692 | Pituitary and Neuroendocrinology | ECE2023

Macrohormones (“incidental hormones”) – a diagnostic challenge in endocrinology: macro-ACTH

Vanuga Peter , Urbankova Helena , Sagova Ivana , Kulich Michal , Huba Peter , Vanuga Anton

Background: If the laboratory results are not compatible with the patient’s clinical symptoms, the presence of possible test interference should be considered. Despite the excellent quality of immunoassays, it is currently estimated that they may be susceptible to several types of interference that may lead to patient misdiagnosis.Case report: In our case report we present a 71-year-old woman with confirmation of macro-adrenocorticotropic hormone (m...