Searchable abstracts of presentations at key conferences in endocrinology

ea0044ep87 | (1) | SFEBES2016

Thionamide in a Neutropenic Thyrotoxic patient- Culprit or Cure

Kumar P

A 59 yr old man was admitted with sweating, tremors and generalized weakness. Blood tests showed FT4>100 pmol/l, FT3>50 pmol/l, TSH<0.01 mU/l, neutrophils 0.6×109 /l Past medical history included recurrent hyperthyroidism, type 2 diabetes mellitus, and neutropenia of ‘unknown’ origin(under investigation by haematology). Carbimazole 20 mg BD was started 2 days prior to admission by his general practitioner.The neutrop...

ea0029p691 | Diabetes | ICEECE2012

Antihyperglycemic effects of sodium orthovanadate and Trigonella foenum graecum in diabetic rats

Kumar P. , Kale R. , Baquer N.

Objectives: Oral administration of vanadate to diabetic animals have been shown to stabilize the glucose homeostasis and restore altered metabolic pathways. The present study explored the prospect of using low doses of vanadate with Trigonella foenum graecum, seed powder (TSP), another antidiabetic agent, and to evaluate their antidiabetic effect in diabetic rats. The effect of these antidiabetic compounds was examined on general physiological parameters, monoamine oxidase act...

ea0029p759 | Endocrine Disruptors | ICEECE2012

Bisphenol-A exposure from electronic gadgets: A risk assessment

Kumar N. , Khan R. , Kumar P. , Sharma V.

We are living in the electronic era and day to day exposed by estrogenic disruptors such as Bisphenol-A (BPA). Electronic gadgets such as cellular phones, CDs, DVDs, RFIDs even baby feeding bottles are made with composition of BPA and their huge application are matter of debate in present. The chronic exposures of BPA have become a major health concern. In this study we assessed the neurobehavioral alterations caused by BPA in the rats. We examined the neurobehavioral changes ...

ea0029p1074 | Neuroendocrinology | ICEECE2012

Mechanisms for the protective effects of 17-β-estradiol: relevance to depressive symptoms in Parkinson’s disease

Kumar P. , Kale R. , Cowsik S. , Baquer N.

Background: Parkinson’s disease (PD) is a neurodegenerative disease and a movement disorder characterized by loss of dopaminergic neurons in the substantia nigra causing dopamine depletion in the striatum. Neurodegeneration in PD occurs due to multiple pathways including oxidative stress, mitochondrial damage, protein aggregation. These changes increase during menopausal condition in females when the level of estradiol is decreased. Recently, there has been a growing inte...

ea0024p35 | (1) | BSPED2010

NAFLD in type 1 DM: a report of 2 cases

Kumar P , Ghatak A , Blair J C , Didi M , Paul P

Introduction: Non-alcoholic steatohepatitis (NASH) is part of the spectrum of non-alcoholic fatty liver disease (NAFLD). NASH commonly occurs in patients with type 2 DM and is less recognised in type 1 DM. The natural history of NASH in adult patients suggests potential development of progressive fibrosis and cirrhosis. However, secondary glycogenosis, commonly occurs in type 1 DM, is reversible when good glycaemic control is achieved, but may be misidentified as NASH b...

ea0017p13 | (1) | BSPED2008

Short-term height gain in boys with constitutional delay of growth and puberty treated with testosterone esters or enantate

Gardner C , Kumar P , Banerjee I , Didi M , Blair J

In boys with constitutional delay of growth and puberty (CDGP), puberty may be induced with a short course of testosterone, either as esters or enantate injections. While both types of testosterone are known to be effective in inducing puberty, there are no studies comparing their efficacies. We have compared height gain, a quantitative marker of puberty, between boys treated with a short course of testosterone esters and enantate injections in a retrospective, observational s...

ea0015p360 | Thyroid | SFEBES2008

The one-stop thyroid clinic: what’s the rush?

Lewis DH , Goulden P , Kumar J , Barnes DJ

A 64-year-old man presented with mild biochemical hyperthyroidism – TSH <0.01 mU/l (NR 0.35–4.90), FT4 19.4 pmol/l (NR 9–19) in 2005. He was treated by his general practitioner with a 9 months course of carbimazole. Six months later, TSH became suppressed (0.05 mU/l) but with a normal fT4 (17 pmol/l). He was referred to a ‘One-Stop’ Thyroid Clinic and was seen there 3 months later. Thyroid isotope scan showed a toxic multinodular goitre. He was tre...

ea0007p49 | Diabetes, metabolism and cardiovascular | BES2004

Increased C-jun N terminal kinase (JNK) activity may link insulin resistance and inflammation in human central obesity

Fowler A , Silva N , Burman C , Harte A , McTernan P , Kumar S

Central obesity is strongly associated with insulin resistance and chronic sub-clinical inflammation, which is implicated in the development of type 2 diabetes (T2DM). However, the mechanisms underlying this link remain unclear. Recently JNK, a mitogen activated protein kinase (MAPK), has been implicated in obesity and insulin resistance by interfering with insulin action. Studies in rodent models show that phosphorylated JNK-1 is elevated in obesity, whilst the absence of JNK...

ea0086p295 | Thyroid | SFEBES2022

Radioactive Iodine treatment (RAI) for benign thyroid disease: ESHT outcomes

Mizanour Rahman Md , Ravelo Maria , Gupta Sheena , Salt Chris , Sathis Kumar P

Introduction: Following a National training programme for Endocrinologists to provide RAI treatment for benign thyroid disease, the ESHT NHS Trust started Radioactive iodine (RAI) treatment for benign thyroid disease a couple of years ago. Previously ESHT trust patients were referred to neighbouring trusts for RAI treatment.Data/Results: The data was collected over a 12-18 month period. A total of 34 patients received RAI treatment during this period; 28...