Searchable abstracts of presentations at key conferences in endocrinology

ea0019p315 | Steroids | SFEBES2009

Orexin-stimulated MAP Kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: differential regulation by orexin A and orexin B

Chen Jing , Ramanjaneya Manjunath , Conner Alex , Kumar Prashanth , Brown James , Johren Olaf , Lehnert Hendrik , Stanfield Peter , Randeva Harpal

Orexin-A and orexin-B orchestrate their diverse central and peripheral effects via two G-protein coupled receptors, OX1R and OX2R, which activate multiple G-proteins. They are involved in a host of physiological processes including, steroidogenesis, appetite control and energy regulation. Whilst some signalling mechanisms have been proposed for individual recombinant orexin receptors in generic mammalian cell types, it is clear that the peripheral effects of orexin are spatial...