Searchable abstracts of presentations at key conferences in endocrinology

ea0019p146 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Metformin decreases angiogenesis via ERK1/2/ERK5 pathways by increasing the anti-angiogenic adipokine thrombospondin-1

Tan Bee , Kumar S Prashanth , Chen Jing , Heutling Dennis , Mitchell Dan , Lehnert Hendrik , Randeva Harpal

Aims: Polycystic ovary syndrome (PCOS) is associated with insulin resistance, obesity and cardiovascular complications. Thrombospondin-1 (TSP-1) is a novel anti-angiogenic adipokine highly expressed in obese, insulin-resistant subjects. We sought to assess TSP-1 levels in adipose (AT) from PCOS women and matched controls. The effects of metformin treatment on circulating TSP-1 levels in PCOS subjects; effects of serum from normal and PCOS women on in vitro migration and...