Searchable abstracts of presentations at key conferences in endocrinology

ea0044p5 | Adrenal and Steroids | SFEBES2016

Outcomes of annual surveillance imaging in an adult and paediatric cohort of succinate dehydrogenase B mutation carriers

Tufton Nicola , Shapiro Lucy , Srirangalingam Umasuthan , Richards Polly , Sahdev Anju , Kumar V K Ajith , Chew Shern L , Drake William M , Storr Helen , Akker Scott A

Introduction: Germline mutations in succinate dehydrogenase subunit B (SDHB) are one of the commonest findings in familial paraganglioma (PGL) syndromes and account for one quarter of PGLs associated with germline mutations. Although the penetrance is low, the malignancy conversion is high; up to 30%. With the increasing availability of genetic testing and the identification of ‘asymptomatic carriers’ of the SDHB gene mutation, it is therefore impor...