Searchable abstracts of presentations at key conferences in endocrinology

ea0032p246 | Clinical case reports – Pituitary/Adrenal | ECE2013

Thalassemia minor associated with multiple pituitary hormone deficiency

Szanto Zsuzsanna , Kun Imre Zoltan , Oltean Galafteon

Regular red blood cell transfusions for thalassemia major leads to iron overload in endocrine glands, inducing deficient function of the pituitary, thyroid, parathyroid etc. In thalassemia intermedia these endocrine disturbances may appear due to increased intestinal iron absorption and occasional transfusions, but are less frequent and milder. We have no data about their presence in thalassemia minor.We present the case of a young woman known with mild ...

ea0020p109 | Thyroid | ECE2009

Incidental and nonincidental papillary thyroid microcarcinomas in the material of Endocrinology Clinic and Institute of Pathology, Targu Mures

Szanto Zsuzsanna , Kun Imre Zoltan , Jung Janos

Objective: To study thyroid microcarcinomas in surgical samples obtained by thyroidectomy.Material and methods: We studied 311 patients thyroidectomized for different thyroid diseases in 2007, histology being made in the Institute of Pathology Tg.Mures.Results: Surgery was made for uni- and multinodular goiter in 278, for Graves-disease in 28, and for other forms of hyperthyro-i-dism in 5 cases. Thyroid cancer was diagnosed in 65 c...

ea0016p705 | Thyroid | ECE2008

Thyroid function of pregnant women hospitalized in a section of gestational pathology

Szanto Zsuzsanna , Kun Imre Zoltan , Szabo Bela

In our previous studies, we determined the incidence of thyroid dysfunctions in pregnant women in endocrinological out-patient departments, comparing the frequency and nature of gestational complications in hypothyroid pregnant women versus pregnants without thyroid disturbances. In the present study, we proposed to appreciate thyroid dysfunctions in a clinical section of pregnant women with gestational pathology. We investigated 75 pregnant women hospitalized in the Clinic of...

ea0041ep1070 | Thyroid (non-cancer) | ECE2016

The course of chronic autoimmune thyroiditis in pregnant women during iodine and selenium therapy

Szanto Zsuzsanna , Csiszer Attila , Kun Imre Zoltan , Croitorescu Zsuzsanna

Introduction: In iodine deficient regions maternal iodine supply is indispensable for the normal development of the fetus, but it might aggravate autoimmune thyroid diseases in the mother during pregnancy and postpartum. Selenium might be beneficent in these thyroid diseases by defending against the harmful effect of iodine on maternal thyroiditis.Objective: To study the course of Hashimoto’s thyroiditis in pregnant women, under combined therapy wit...

ea0037ep959 | Thyroid (non-cancer) | ECE2015

Difficulties in the interpretation of urinary iodine excretion in pregnant women

Szanto Zsuzsanna , Csiszer Attila , Croitorescu Zsuzsanna , Kun Imre Zoltan

Introduction: The urinary iodine excretion (UIE) from fasting morning urine sample is a good epidemiologic indicator for iodine state, used in populational groups (schoolchildren, pregnant women) at risk to develop iodine deficiency disorders. It is not adequate to evaluate individual iodine intake. In pregnant women, especially with chronic autoimmune thyroiditis, it is important to estimate iodine state.Objectives: To evaluate the individual iodine sta...

ea0032p250 | Clinical case reports – Pituitary/Adrenal | ECE2013

Newly discovered adrenal tumor and pituitary microadenoma in a patient known with classical congenital adrenal hyperplasia

Kun Imre Zoltan , Szanto Zsuzsanna , Albert Karola , Patocs Attila

Introduction: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder, most commonly caused by CYP21A2 mutations, and characterized by disturbed cortisol and androgen synthesis. Clinical manifestations of classical 21-hydroxylase deficiency are virilisation and salt-waisting syndrome in both sexes. Adrenal tumors may appear in untreated CAH patients, but very rarely following adequate long-term therapy.Case report: The 17-years-old male p...

ea0016p704 | Thyroid | ECE2008

Refetoff syndrome associated with other congenital diseases (case report)

Kun Imre Zoltan , Szanto Zsuzsanna , Vicsi Ildiko , Reti Zsuzsanna

We report the case of a 25-year-old woman (K.Cs.) hospitalized in our clinic for endocrinological investigation, presenting a spontaneous abortion 3 weeks before hospitalization. From medical history, we mention a cerebral thrombophlebitis with intracranian hypertension syndrome, appeared after oral contraceptive drug (Diane 35R) used for 5 months. The clinically asymptomatic patient presented diffuse goiter (I. gr.), overweight and virilism, without other clinical ...

ea0041ep805 | Obesity | ECE2016

Aripiprazole effects on triglyceride content of in vitro differentiating adipocytes

Kolcsar Melinda , Gall Zsolt , Tabi Tamas , Baba Laszlo Istvan , Koncz Szabolcs , Kun Imre Zoltan

Introduction: In vitro adipogenesis is a two-step developmental process in which an undifferentiated mesenchymal cell differentiates into a preadipocyte, which then undergoes a secondary differentiation step to become a lipid-filled adipocyte. The triglyceride accumulation is influenced by various endogenous and exogenous factors.Methods: In an attempt to understand the antipsychotics effects on lipid accumulation duri...

ea0037ep794 | Pituitary: clinical | ECE2015

Multimodal management of GH-secreting pituitary adenomas – the experience of the endocrinology department Tirgu-Mures, Romania, in the last decade

Kun Imre Zoltan , Tanko Zsuzsa , Nasalean Anisie , Balazs Jozsef , Gliga Camelia , Pascanu Ionela , Szanto Zsuzsanna

Introduction: The diagnostical and therapeutical management of GH-secreting pituitary adenomas has been modified in many aspects in the last decade, and the guidelines also have been considerably changed.Objective: To evaluate the management of acromegaly applied in an endocrinological clinical unit from Romania, and the efficiency of different therapeutical schemes.Materials and methods: 23 patients with acromegaly, treated and fo...

ea0032p282 | Clinical case reports - Thyroid / Others | ECE2013

A case of confirmed Smith–Lemli–Opitz syndrome

Kun Imre Zoltan , Szanto Zsuzsanna , Ludke Ibolya , Duka Gabriela , Plaiasu Vasilica

Smith–Lemli–Opitz syndrome (SLOS) is a 46,XY disorder of sex development, included in the subgroup of disorders in androgene synthesis. The disease is caused by mutations of 7-dehydrocholesterol reductase (DHCR7) gene, conducting to deficient synthesis of the correspondent enzyme and of cholesterol, with important role in embryogenesis, adrenal and gonadal steroidogenesis. Clinical manifestations includ facial dysmorphism, syndactyly, ambiguous external genitalia and...