Searchable abstracts of presentations at key conferences in endocrinology

ea0028s12.3 | Medullary thyroid cancer | SFEBES2012

The diagnosis and surgical management of medullary thyroid cancer

Kurzawinski Tom

Medullary thyroid cancer (MTC) accounts for 5–10% of all thyroid cancers and can be either sporadic (75%) or familial (25%). Familial MTC is associated with hereditary syndromes such as Multiple Endocrine Neoplasia (MEN) type 2A or 2B and Familial Medullary Thyroid Cancer (FMTC). Sporadic MTC most often present as thyroid nodule and fine needle aspiration cytology combined with elevated plasma calcitonin levels is diagnostic in about 90% of cases. Hereditary forms of MTC ...

ea0094ns1.1 | Primary Hyperparathyroidism: diagnosis to treatment | SFEBES2023

Primary Hyperparathyroidism: Can innovative technologies improve current diagnostic and therapeutic pathways?

Kurzawinski Tom

Primary Hyperparathyroidism (PHPT) is, after diabetes and thyroid diseases, the third commonest endocrine disorder and its incidence and prevalence is rising globally. In the United Kingdom, the incidence of PHPT has been estimated to be 25/100,000, and prevalence has risen from 1.8 to 6.7 per 1000 between 1997-2006, implying that in the UK alone, about half a million people suffer from this condition and 12.000 develop it each year. Recognition of increased PHPT related morbi...

ea0094ret2.3 | Section | SFEBES2023

Surgical Precision for RET-related tumour syndromes in the era of Precision Medicine

Kurzawinski Tom

Genetic testing for RET gene was available in the United Kingdom within few years of its discovery, undoubtedly another bonus of universal, nationwide health care system. It was the beginning of Precision Medicine era, which became a watchword for preventative and personalized treatments based on phenotypic, biomarker and genetic characteristics. Surgical Precision on the other hand is an idiom for doing something very well and with meticulous attention to detail. In my presen...

ea0038p454 | Thyroid | SFEBES2015

Incidental thyroid malignancy in Grave’s thyrotoxicosis

Rashid Nazia , Kurzawinski Tom , Chung Teng-Teng

Introduction: Correlation of papillary thyroid cancer and lymphocytic thyroiditis is well documented but the incidence of thyroid malignancies in Graves’ disease especially in the absence of nodular thyroid disease is considered to be uncommon.Method: We conducted a retrospective audit of forty-four patients with established diagnosis of Grave’s thyrotoxicosis treated with total thyroidectomy from 2010-2013 (36 months), in a tertiary care centr...

ea0037ep318 | Calcium and Vitamin D metabolism | ECE2015

Raised calcium & PTH, not always a primary hyperparathyroidism

Tabassum Fareeda , Baldeweg Stephanie , Kurzawinski Tom

Case: A 50-years-old gentleman underwent cardiac surgery which was complicated by postoperative arrythmias and ischemic stroke. He was found to have raised calcium of 2.9 (2.2–2.6 mmol/l) subsequent to which PTH was tested and found to be raised at 34.2 (1.6–6.9 pmol/l) which increased to 41.2 pmol/l in few days. He was referred for work up and management of primary hyperparathyroidism. An USS of the neck showed 1.5 cm nodule posterior to left thyroid lobe and Sestim...

ea0094p200 | Endocrine Cancer and Late Effects | SFEBES2023

SURvey of Surgeon’s and Physician’s experiences of GEnetic testing in patients with Familial Endocrine Syndromes: SurGe in UK and Abroad

de Jong Mechteld , Parameswaran Rajeev , Kurzawinski Tom

Introduction: Genetic testing for Familial Endocrine Syndromes has an important role in diagnosis, timing/extent of surgery, and follow-up. Our survey explored experiences and attitudes towards genetic testing in the UK and Abroad.Methods: Attendees of 2022 Conferences of ESES, BSPED, SfE, BAETS and AsianAES were asked to participate in an online survey (31 questions on demographics; genetic testing availability and expe...

ea0086op5.4 | Bone and Calcium | SFEBES2022

Prospective clinical trial of a novel, reusable, pocket size Point of Care device to measure ionized calcium in venous and capillary blood and saliva

Rozalen Garcia Virginia , Abdel Aziz Tarek , Soromani Christina , Kurzawinski Tom

Background: Patients with hypoparathyroidism require frequent calcium measurements and currently there is no point of care device allowing this to be done at home by patients themselves. The aim of our study was to evaluate whether ionized calcium(iCa) can be accurately measured in venous and capillary blood and saliva by a repurposed device LAQUA.(R&D Ref 18/0058– IRAS 236079)Methods: Patients undergoing thyroid and parathyroid surgery underwen...

ea0021p89 | Clinical practice/governance and case reports | SFEBES2009

Severe primary hyperparathyroidism (PHPT) and osteomalacia in pregnancy complicated by post parathyroidectomy hypocalcaemia related transient congestive cardiac failure (CCF): a case report

Thorogood Natasha , Kurzawinski Tom , Conway Gerard , Baldeweg Stephanie

Introduction: PHPT is reported to be rare in pregnancy, with 150 cases described in the literature. Its incidence is 8/100 000 in childbearing women/year. PHPT may lead to a loss of up to 50% of pregnancies through miscarriage or stillbirth, dehydration, hyperemesis, nephrolithiasis, pre-eclampsia, fractures and pancreatitis in mothers; and death, hypocalcaemia and tetany in neonates. Intrauterine growth retardation, low birth weight and pre-term labour were described. Rate of...

ea0021p215 | Endocrine tumours and neoplasia | SFEBES2009

Receptor-based scintigraphic imaging of insulinoma and glucagonoma in MEN-1

Sivappriyan Sivasubramaniam , Kurzawinski Tom , Bomanji Jamshed , Conway Gerard , Ahlquist James

Successful surgery for pancreatic neuro-endocrine tumours (NET) requires accurate tumour localisation. Interpretation of cross-sectional imaging is often difficult, particularly after pancreatic surgery. Imaging by somatostatin-receptor-scintigraphy with indium-labelled octreotide may be useful in identifying recurrent disease; however, octreotide scans may be negative in some pancreatic NET, due to a low level of expression of somatostatin receptors. The GLP-1 receptor is abu...

ea0050p266 | Neuroendocrinology and Pituitary | SFEBES2017

Patterns of recurrence, response to treatment and mortality in patients with malignant phaeochromocytomas and paragangliomas. – a single centre experience

Abdel-Aziz Tarek , Chung Teng-Teng , Bomanji Jamshed , Gaze Mark , Kurzawinski Tom

Introduction: Histology is a poor predictor of the malignant potential of phaeochromocytomas and paragangliomas (PPGL) and only the presence of distant metastasis confirms malignancy. This study reviews patterns of recurrence, treatment and mortality in patients with malignant PPGL presenting to our department at UCLH over 30 years.Materials and Methods: In our series of 128 patients with PPGL, 26 (20%) with maligna...