Searchable abstracts of presentations at key conferences in endocrinology

ea0093oc50 | Oral communication 8: Interdisciplinary Endocrinology and Environment, Society and Governance | EYES2023

Bisphenols in adrenocortical cell culture

Kurzinger Lydia , Potzl Benedikt , Kendl Sabine , Fassnacht Martin , Kurlbaum Max , Dischinger Ulrich

Background: Bisphenol A (BPA) acts as an endocrine disruptor in different endocrine systmes. However, its impact on the adrenal cortex and steroidogenesis is largely unknown. This also applies to its substitute substances bisphenol F (BPF) and S (BPS). Therefore, experiments addressing this subject are urgently needed.Methods: The human adrenocortical cell lines NCI-H295R and MUC-1 were treated with increasing concentrations (1 nM–1 mM) of bisphenol...

ea0099p14 | Adrenal and Cardiovascular Endocrinology | ECE2024

Improved selectivity of adrenal venous sampling with the use of alternative steroids to cortisol

Alessi Francesco , Costantinescu Georgiana , Peitzsch Mirko , Remde Hanna , Kurzinger Lydia , Schulze Manuel , Lee Myron , Yang Jun , Reinke Martin , Beuschlein Felix , Bornstein Stefan , Lenders Jacques , Pamporaki Christina , Eisenhofer Graeme

Background: Current guidelines recommend adrenal vein sampling (AVS) for the identification of surgically treatable unilateral disease among patients with primary aldosteronism (PA). The cortisol-derived selectivity index (SI) is currently used to assess the success (or selectivity) of adrenal vein catheterization during AVS. However, AVS studies can be non-selective in many cases.Aim: To examine whether the use of SI derived either from 11-deoxycortisol...

ea0099oc11.4 | Oral Communications 11: Adrenal and Cardiovascular Endocrinology | Part II | ECE2024

Machine learning-based differentiation of uni- and bilateral primary aldosteronism using circulating microRNA combinations

Vekony Balint , Nyirő Gabor , Herold Zoltan , Fekete Janos , Ceccato Filiipo , Gruber Sven , Kurzinger Lydia , Parasiliti-Caprino Mirko , Szucs Nikolette , Szeredas Balint , Nazri Siti Khadija Syed Mohammed , Fell Vanessa , Bassiony Mohamed , Azizan Elena A B Aisha , Bancos Irina , Beuschlein Felix , Igaz Peter

Background: Primary aldosteronism (PA) is the most prevalent cause of secondary hypertension. Its two main clinical forms are unilateral adenoma (APA) and bilateral hyperplasia (BAH), which require markedly different medical treatments, so differentiating between the two is of utmost clinical importance. The current gold standard method for this is adrenal vein sampling (AVS), the application of which is hindered by limited availability and high skill requirements.AimOur goal ...