Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep1105 | Hot topics (including COVID-19) | ECE2020

MTHFR C677T polymorphism frequency and DNA methylation status in Georgian population with non-autoimmune hypothyroidism

Kvaratskhelia Tamar , Abzianidze Elene , Kakulia Mzeona , Surmava Sandro , Asatiani Ketevan , Kvaratskhelia Eka

Introduction: Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism results in thermolabile, reduced functioning enzyme and predicts hyperhomocisteinemia and altered DNA methylation. On the other hand, several studies indicated a higher plasma homocysteine (Hcy) levels in patients with primary hypothyroidism than in healthy, euthyroid individuals, including some experimental studies that indicated decreased MTHFR activity in hypothyroid patients. We cond...