Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep607 | Obesity and cardiovascular endocrinology | ECE2015

Audit of metabolic profiles in women with Turner syndrome

Kyithar Ma Pyeh , McQuaid Siobhan

Introduction: Adults with Turner syndrome (TS) are at increased risk of cardiovascular morbidity and mortality. The aim of this study was to evaluate the compliance with clinical guidelines (Bondy 2007) in measuring metabolic profiles in adults with TS.Methods: Case notes of patients attending a dedicated TS clinic were studied. Variables assessed included anthropometric measurements, blood pressure (BP), fasting plasma glucose (FPG), HbA1c, fasting lipi...

ea0063p413 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Phenotypic variability within a family with multiple endocrine neoplasia type 1 (MEN1) syndrome

Ahmad Tariq , Sharma Jayant , Crowley Rachel , Kyithar Ma Pyeh

MEN1 is an autosomal dominant endocrine tumour syndrome, caused by inactivating mutations of the MEN1 tumour suppressor gene at 11q13 locus and characterised by occurrence of hyperparathyroidism, pancreatic tumours and pituitary adenomas. We describe a family with MEN1 syndrome. The index case was a 71-year-old man, referred to Endocrinology clinic in Midland Regional Hospital Portlaoise for hypercalcemia (calcium 3 mmol/l, phosphate 0.5 mmol/l, PTH 350 pg/ml, creatin...

ea0070ep236 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Type 1 diabetes and challenges ahead

Batool Maria , Qadeer Abdul , Sharma Jayant , Kyithar Ma Pyeh

The incidence of type 1 diabetes mellitus (T1DM) is rising. The demands of daily management, blood glucose variability and potential complications pose challenges in management of T1DM.The aim of this study was to determine the clinical and metabolic profiles of T1DM patients attending Midland Regional Hospital Portlaoise diabetes service in 2017 and to assess their microvascular and macrovascular complications.A retrospective anal...

ea0073aep191 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Erythrocytosis in a patient on sodium glucose cotransporter-2 inhibitor

Byrne Shane , Nor Mohammad Aiman , Crotty Gerard , Kyithar Ma Pyeh

BackgroundSodium glucose cotransporter-2 (SGLT-2) inhibitors have proven valuable in the management of type 2 diabetes. These agents are particularly effective in reducing hospitalisations with heart failure and cardiovascular mortality. Adverse effects are primarily centred on urogenital infections and hypovolaemia. Here, we report the case of a patient who developed asymptomatic erythrocytosis while taking empagliflozin.Case repo...

ea0037ep1202 | Clinical Cases–Pituitary/Adrenal | ECE2015

Exaggerated cortisol response in heterozygous carriers with a mutation in the melanocortin-2 receptor (MC2R) gene

Kyithar Ma Pyeh , Green Andrew , Hughes Claire , Murphy Nuala , Byrne Maria

Introduction: Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disease characterised by ACTH resistance and isolated glucocorticoid deficiency. Mutations of ACTH receptor, known as melanocortin-2 receptor (MC2R), and melanocortin-2 receptor accessory protein (MRAP) account for approximately 25 and 15 to 20% of cases respectively. To date there is no strong evidence that heterozygous carriers have abnormal cortisol secretion.Case: We...

ea0070aep89 | Adrenal and Cardiovascular Endocrinology | ECE2020

Apparent mineralocorticoid excess (AME): Finding the “root” cause

Kyithar Ma Pyeh , Blasiak Tomasz , Kodandapani Srinivasachar , Kumari Meena , McHugh Joseph

Liquorice is a sweetener found in many food products, soft drinks, snacks and herbal medicines. Liquorice ingestion is an uncommon cause of AME or pseudohyperaldosteronisim. The mechanism involves the inhibition of 11-beta-hydroxysteroid dehydrogenase type-2 by the active ingredient called glycyrrhizin, which leads to the uninhibited activation of mineralocorticoid receptors by cortisol. Confectionary products that contain liquorice are readily available in the European Union....

ea0037ep1119 | Endocrine tumours | ECE2015

Audit of patients with multiple endocrine neoplasia type 1 (MEN1): screening of pancreatic neuroendocrine tumours (pNETs), parathyroid tumours and pituitary adenomas

Kyithar Ma Pyeh , Cullen Lisa , Lee Chun , Swan Niall , Geoghegan Justin , Skehan Stephen , Crowley Rachel , O'Shea Donal , O'Toole Dermot

Introduction: Patients with MEN1 have increased morbidity and mortality compared to those patients with sporadic NETs. No genotype-phenotype correlation is described and age-related clinical penetrance surpasses 50 and 90% by 20 and 40 years, respectively. The aim of the audit was to compare the screening programme for MEN1 patients with MEN1 clinical guidelines.Methods: Case notes of MEN1 patients attending a tertiary NET-multidisciplinary team (MDT) in...