ea0012p53 | Diabetes, metabolism and cardiovascular | SFE2006
, Pritchard LE
, Brennand JC
, White A
The proglucagon-derived hormone, glucagon-like peptide1 (GLP-1), augments both beta cell function and mass. However, GLP-1 is rapidly degraded in plasma, thereby limiting its potential as a treatment for diabetes. One approach to circumvent this problem would be to stimulate synthesis of GLP-1 locally in the islet.Emerging evidence suggests that pancreatic alpha cells, which normally produce glucagon, can adapt to produce GLP-1. This phenomenon may...