Searchable abstracts of presentations at key conferences in endocrinology

ea0098c56 | Clinical – Surgery/Applied Pathology | NANETS2023

Comparative gene expression and pathway analysis of neuroendocrine neoplasms in relation to clinical outcomes and tumor location

Laderian Bahar , Saberzadeh Ardestani Bahar , Chen Yanwen , Mohamed Amr , Ni Ying , Mundi Prabhjot

Background: Neuroendocrine malignancies are heterogeneous cancers with varied clinical outcomes. The molecular landscape driving this heterogeneity has not yet been fully characterized. We aimed to investigate the gene expression profiles of neuroendocrine neoplasms, in relationship to baseline clinicopathological features and clinical outcomes, to elucidate underlying biology and potential therapeutic targets.Methods: Patients with neuroendocrine tumors...

ea0089p5 | Population Science | NANETS2022

Comparison of Demographics and Overall Survival (OS) Among Patients with Young-Onset(YO) and Late-Onset(LO) GI Neuroendocrine Tumors/Carcinomas (NETs/NECs) in the United States

Laderian Bahar , Farha Nicole , Khorana Alok , Krishnamurthi Smitha , (Auston) Wei Wei , Estfan Bassam , Gorgun Emre , Berber Eren , Gill Amanjit , Fojo Tito

Background: More than 12,000 people are diagnosed with neuroendocrine malignancies each year in the US. There are limited data on YO-NETs/YO-NECs. In the present study, we seek to evaluate clinical characteristics/trends of patients with GI-YO-NETs and GI-YO-NECs.Methods: Using the National Cancer DataBase, NCDB, we identified 124,081 GI-NETs and 52,063 GI-NEC cases 18 or older, diagnosed between 2004 and 2019. Histology codes to identify NETs and NECs w...