Searchable abstracts of presentations at key conferences in endocrinology

ea0016p432 | Neuroendocrinology | ECE2008

GHRH as a possible allosteric ligand of the ghrelin receptor GHS-R1a

Carreira Marcos C , Camina Jesus P , Lage Mary , Casanueva Felipe F

Ghrelin and GHRH are two hormones involved in the growth hormone (GH) secretion through their respective receptors. The growth hormone secretagogue receptor subtype 1a (GHS-R1a) is involved in biological actions exerted by ghrelin triggering intracellular second messengers coupled to Gαq/11 protein. In this work, we analyzed the possible interaction between GHRH and GHS-R1a as well as the subsequent intracellular pathways. The results showed that GHRH induced, ...

ea0016p481 | Neuroendocrinology | ECE2008

Hypopituitarism after traumatic brain injury and its possible relation with neurocognitive and psychiatric disturbances

Castro Ana I , Lage Mary , Peino Roberto , Lorenzo Monica , Casanueva Felipe

Introduction: Recent advances in medicine have allowed a considerably decrease in mortality after traumatic brain injury (TBI) with the consequent increment in the number of subjects with physical, psychological and cognitive sequelas which means an important worsening of quality of life as well as difficulties in social and labour integration. Considering that many of the symptoms classically attributed to the TBI (memory impairment, concentration impairment, fatigue, social ...

ea0013p254 | Reproduction | SFEBES2007

Ghrelin is reduced in women with polycystic ovary syndrome and correlates inversely with HOMA IR and testosterone

Barber Thomas M , Casanueva Felipe F , Lage Mary , Franks Stephen , McCarthy Mark I , Wass John AH

Introduction: Ghrelin is a novel peptide involved in the regulation of appetite and energy balance. Dysregulation of ghrelin may play a role in the development of obesity in polycystic ovary syndrome (PCOS). Due to the strong association between BMI and PCOS, we hypothesised that obese women with PCOS have abnormal fasting and post-glucose load ghrelin levels compared with BMI-matched control women.Methods: Datasets included 18 women with PCOS, all with ...

ea0026p225 | Pituitary | ECE2011

Effect of GH as add-on treatment in severe fibromyalgia syndrome. Results from the IIIb, CT27560 placebo-controlled, multicenter trial

Cuatrecasas Guillem , Alegre Cayetano , Sola Joaquim Fernandez , Gonzalez Maria Jose , Lage Mary , Sesmilo Gemma , Granados Enrique , Domingo Manuel Puig

Introduction: Functional GH deficiency has been described in fibromyalgia (FM). The efficacy of GH as add-on treatment has been suggested in small studies, but little is known in larger and homogeneous populations.Design: Patients (120) were enrolled in a multicenter, randomized, placebo-controlled trial for 18 months (NCT00933686). FM impact questionnaire (FIQ) >75 (severe), duration of FM >18 months, and stability of the standard therapy (amitr...