Searchable abstracts of presentations at key conferences in endocrinology

ea0063oc14.3 | Sex Hormones | ECE2019

First identification of bone morphogenic protein receptor variants as a cause of primary ovarian insufficiency

Beau Isabelle , Renault Lucie , Patino Liliana , Magnin Francoise , Delemer Brigitte , Laissue Paul , Young Jacques , Binart Nadine

Bone morphogenetic proteins (BMPs) exhibit broad spectrum of biological activities in various tissues, including bone, cartilage, blood vessels, heart, kidney, neurons, liver and lung. BMPs are members of the transforming growth factor-β (TGF-β) family that bind to type II and type I serine-threonine kinase receptors, and transduce signals through Smad and non-Smad signalling pathways. BMPs together with other intraovarian growth factors are intimately involved in re...