Searchable abstracts of presentations at key conferences in endocrinology

ea0014p414 | (1) | ECE2007

CYP3A7*1C polymorphism, serum dehydroepiandrosterone sulphate level and bone mineral density in postmenopausal women

Speer Gábor , Bácsi Krisztián , Kósa János P. , Lakatos Péter

Objective: The CYP3A7 enzyme metabolizes some steroid hormones including dehydroepiandrosterone sulphate (DHEAS). Its expression silenced after birth. Previous study has shown that in case of CYP3A7*1C polymorphism, CYP3A7 enzyme activity persisted a higher level, resulting lower levels of DHEAS in men. The age-related decline of serum DHEAS levels is believed to contribute to osteoporosis. We hypothesized that CYP3A7*1C contribute bone loss through decreased level of serum DH...

ea0029p1760 | Thyroid cancer | ICEECE2012

Remarkable enhance in CYP24A1 expression in human thyroid cancer tissue

Balla B , Kosa J , Tobias B , Halaszlaki C , Takacs I , Horvath H , Speer G , Horanyi J , Nagy Z , Jaray B , Szekely E , Lakatos P

Background: It is well established that 1,25-dihydroxyvitamin D3 (1,25-D3) inhibits cell growth and induces apoptosis in numerous tumors. Increased expression of 1,25-D3 inactivating enzyme, (24-hydroxylase - CYP24A1), has been observed in numerous thyroid cancer cell lines after calcitriol treatment in vitro. We examined the expression of CYP24A1 as well as the activating 1-α-hydroxylase (CYP27B1) gene in human thyroid cancer tissue.Methods:...

ea0029p1838 | Thyroid cancer | ICEECE2012

Comparative examination of somatic oncogene mutation normal and pathologic thyroid tissues of Hungarian patients

Tobias B , Balla B. , Kosa J. , Horanyi J. , Takacs I. , Bolony E. , Halaszlaki C. , Nagy Z. , Speer G. , Jaray B. , Szekely E. , Istok R. , Lakatos P.

It is established that somatic oncogene mutation (BRAF, NRAS, HRAS, KRAS) and gene translocations (RET/PTC, PAX8/PPAR-gamma) are associated with the development of thyroid cancer. Somatic single nucleotide polymorphisms were analyzed by LigthCycler melting method, while translocations were identified by real-time polymerase chain reaction technique. In 22 intraoperative thyroid tissue samples (11 pathologic and 11 normal). In tumorous sample 3 BRAF, 2 NRAS and one HRAS mutatio...