Searchable abstracts of presentations at key conferences in endocrinology

ea0022p557 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Plasma ghrelin concentrations in narcoleptic patients

Lakocevic Milan , Petakov Milan , Rajsic Nenad , Macut Djuro , Antic Jadranka , Popovic Vera , Damjanovic Svetozar

Background: Narcolepsy is hypersomnia of central origin whose clinical features are excessive daytime sleepiness, hypnagogic hallutinations, sleep paralysis and cataplexy which comprises sudden transient loss of muscle tone often triggered by emotions. Narcolepsy with cataplexy is assiociated with hypocretin 1/orexin-A (HCRT 1/ORX-A) deficiency in central nervous system. Because of the link between ghrelin and HCRT 1/ORX-A wake-promoting effects there might be ghrelin deficien...

ea0022p758 | Thyroid | ECE2010

Increased frequency of the glucocorticoid receptor gene polymorphisms in patients with autoimmune thyroid diseases

Antic Jadranka , Petakov Milan , Ognjanovic Sanja , Dragicevic Neda , Lakocevic Milan , Damjanovic Svetozar

Background: Glucocorticoids (GCs) have an important modulatory influence on immune system. GCs accomplish their effects on target tissue through binding to the glucocorticoid receptor (GR). Alterations in glucocorticoid signaling due to polymorphisms of the GR gene may have an impact on the pathophysiology of autoimmune disorders.Aims/methods: We examined the presence of BclI, N363S, A3669G and ER22/23EK GR gene variants in patients with autoimmun...