Searchable abstracts of presentations at key conferences in endocrinology

ea0035p467 | Diabetes therapy | ECE2014

Diabetic ketoacidosis simulator: a new learning tool for a life threatening condition

Huguet Isabel , Alfaro J Joaquin , Gonzalvo Cesar , Lamas Cristina , Hernandez Antonio , Botella Francisco

Introduction: Diabetic ketoacidosis (DKA) remains a life threatening complication in type 1 diabetes. Appropiate initial management is crucial in the evolution of this complex condition, and mistakes in the treatment are not uncommon.Medical simulation technology is a powerful tool for training physicians but papers dealing with DKA simulators are scarce.We introduce a new simulator designed in our institution aimed to junior docto...

ea0056gp138 | Neuroendocrinology | ECE2018

Hypermethylation of tumour suppressor genes in pituitary adenomas: contribution to oncogenesis and tumour behaviour

Garcia-Martinez Araceli , Sottile Johana , Fajardo Carmen , Camara Rosa , Lamas Cristina , Pico Antonio

Introduction: Epigenetic and genetic alterations contribute to cancer initiation and progression. These alterations may be playing a determinant role in the development of pituitary adenomas (PAs). One of these epigenetic processes is the DNA methylation and, specifically, methylation of Tumour Suppressor Genes (TSG). TSG are key elements that allow the maintenance of cellular homeostasis. Due to epigenetic changes are reversible, a better understanding of the underlying epige...

ea0056p17 | Adrenal cortex (to include Cushing's) | ECE2018

Clinical and biochemical outcomes in surgically treated patients with primary aldosteronism. A multicentric retrospective study

Vicente Almudena , Sirvent Alejandro , Herranz Sandra , Lamas Cristina , Martinez Ana , Sastre Julia

Background: Although unilateral primary aldosteronism (PA) is the most common surgically correctable cause of hypertension, no standard criteria exist to classify surgical outcomes. The Primary Aldosteronism Surgical Outcome (PASO) study was an international project to develop consensus criteria for outcomes and follow-up of adrenalectomy for unilateral PA.Objetives: To determine the proportions of patients achieving complete, partial, or absent clinical...

ea0063gp167 | Obesity (1) | ECE2019

Epigenetic regulation by miRNAs in corticotroph tumors

Garcia-Martinez Araceli , Lopez-Munoz Beatriz , Fajardo Carmen , Camara Rosa , Lamas Cristina , Torregrosa Maria Eugenia , Aranda Ignacio , Pico Antonio

Introduction: The silencing mechanisms of corticotroph tumors (CT) remain unclear. The most feasible hypothesis lies in a post-transcriptional deregulation of the POMC gene, precursor of ACTH. Micro RNAs (miRNAs) are small non-coding RNA molecules involved in the epigenetic regulation of gene expression through their inhibitory action on messenger RNA. miRNAs capable of inhibiting the expression of POMC have been described at the level of neurons of the hypot...

ea0063p715 | Pituitary and Neuroendocrinology 2 | ECE2019

Silent somatotroph tumors

Garcia-Martinez Araceli , Lloret Adriana , Torregrosa Maria Eugenia , Silva Sandra , Lamas Cristina , Fajardo Carmen , Camara Rosa , Aranda Ignacio , Pico Antonio

Introduction: Silent somatotroph tumors (sST) are a pituitary neuroendocrine tumor subtype with positive immunostaining for growth hormone (GH) but without the presence of acromegaly. Unlike silent corticotroph tumors, there is little information in the literature on sST. The aim of the present study was to study the demographic, clinical and molecular characteristics in a series of ST in order to compare sST and functioning ST (fST).Methods: We have stu...

ea0037gp.18.08 | Pituitary–Basic and IGF-1 | ECE2015

Role of miR-375 in oncogenesis of pituitary adenomas

Sanchez-Tejada Laura , Sanchez-Ortiga Ruth , Riesgo Pedro , Abarca Javier , Fajardo Carmen , Monjas Irene , Camara Rosa , Lamas Cristina , Pico Antonio

Purpose: MicroRNAs (miRNAs) are a fundamental component of gene regulation mechanisms. Presently, altered miRNA patterns of expression have been documented in different human cancers, and they may explain the distinct behavior of pituitary adenomas (PA) and the differences between subtypes. miR-375 can target among other genes to IGF1 receptor (IGF1R) and participes in reprogramming cancer cell metabolism. The aim of this study was to assess the miR-375 role on pathogenesis of...

ea0037gp.18.09 | Pituitary–Basic and IGF-1 | ECE2015

Molecular classification of pituitary adenomas

Pico Antonio , Sanchez-Tejada Laura , Sanchez-Ortiga Ruth , Camara Rosa , Lamas Cristina , Abarca Javier , Monjas Irene , Riesgo Pedro , Fajardo Carmen

Purpose: The 2004 edition of the WHO text ‘Histological typing of endocrine tumors’ classified pituitary adenomas (PA) on the basis of their histological and immunohistochemical characteristics. Recent advances on the knowledge of the molecular patterns of these tumours may allow establishing a molecular classification with higher accuracy and specificity than previous one.Methods: Within the pale of the multicenter Spanish Molecular Registry o...

ea0037ep669 | Pituitary: basic and neuroendocrinology | ECE2015

MiR-7 has a role in behaviour of somatotroph adenomas

Sanchez-Ortiga Ruth , Sanchez-Tejada Laura , Lamas Cristina , Camara Rosa , Abarca Javier , Monjas Irene , Riesgo Pedro , Fajardo Carmen , Pico Antonio

Purpose: IGF receptor 1 (IGF1R) and epidermal growth factor receptor (EGFR) are receptors tyrosine-kinase (RTK) whose altered signaling are critical factors in development of many types of tumours. These RTK are some of the main targets of the microRNA miR-7. This important tumor supressor miRNA has the ability to inhibit the motility, invasiveness and anchorage-independent growth, suggesting a strong therapeutic potential in many types of cancer. Pituitary adenomas (PA) are a...

ea0037ep737 | Pituitary: clinical | ECE2015

Clinical features of pituitary adenomas in elderly patients in Castilla La Mancha (Spain) compared with younger age group; a retrospective multicentre study

Vicente Almudena , Val Florentino Del , Cortes Claudia , Lamas Cristina , Aguirre Miguel , Silva Julia , Alramadan Moubarak , Quiroga Ivan

Background: Pituitary adenomas (PAs) in the elderly, defined as people older than 65 years, represent less than 10% of all PAs. Because of increasing life expectancy and improving health care, diagnosis PAs in this age group is increasing with time. Age-related changes and associated diseases may significantly modify the clinical presentation in these patients, delaying the diagnosis of PAs.Objective: To analyse the clinical features of PAs in elderly pa...

ea0056gp139 | Neuroendocrinology | ECE2018

Why don’t corticotroph tumours always produce Cushing disease?

Garcia-Martinez Araceli , Cano David , Gil Joan , Fajardo Carmen , Camara Rosa , Lamas Cristina , Soto Alfonso , Puig Manel , Webb Susan M

Introduction: Silent corticotroph tumours (SCT) are a pituitary tumours (PT) subtype of corticotroph lineage that do not clinically express Cushing disease. Inmunohistochemical (IHC) studies reveal no differences between SCT and functioning corticotroph tumours with Cushing Syndrome (FCT). However, the silencing mechanisms of this type of tumours are not fully understood.Aim: In an important series of SCT, to sequence the POMC gene and quantify ...