Searchable abstracts of presentations at key conferences in endocrinology

ea0063s27.3 | What's new in reproductive endocrinology? | ECE2019

Menopause and cardiovascular risk

Lambrinoudaki Irene

The transition to menopause is characterised by a decrease in circulating estradiol, relative androgen excess and a decrease in sex hormone-binding globulin concentrations. These hormonal changes are frequently accompanied by an increase in body weight, central obesity, dyslipidemia, insulin resistance and an increase in blood pressure. Aging, comorbidities, depression and inactivity further contribute to the increase in cardiovascular risk after the menopause. Beyond traditio...

ea0049ep214 | Bone & Osteoporosis | ECE2017

Efficacy and safety of bisphosphonate discontinuation in postmenopausal osteoporosis: a systematic review

Anagnostis Panagiotis , Paschou Stavroula , Mintziori Gesthimani , Lambrinoudaki Irene , Goulis Dimitrios

Introduction: The maximum period of bisphosphonate use has not been determined, as their long-term appliance has been associated with adverse effects, such as osteonecrosis of the jaw (ONJ) and atypical femoral fractures (AFF).The aim of this study was to systematically present existent data regarding the effect of bisphosphonate discontinuation on fracture risk and bone mineral density (BMD).Methods/design: MEDLINE, Scopus, EMBASE...

ea0065p222 | Metabolism and Obesity | SFEBES2019

FSH levels are adversely associated with markers of regional adiposity in postmenopausal women

Armeni Eleni , Augoulea Areti , Rizos Demetrios , Kaparos George , Panoulis Konstantinos , Lambrinoudaki Irene

Background: A growing body of evidence reports implications of a direct extra-gonadal effect of follicle stimulating hormone (FSH), involving the development of obesity. The aim of this study was to evaluate the associations between traditional and local obesity indices and FSH concentrations in women after menopause.Methods: We evaluated a total of 420 postmenopausal women in a cross-sectional design (age 55.6±6.5 years, BMI were 25.8±4.0 kg/m...

ea0067o22 | Oral Presentations | EYES2019

Anthropometric and hormonal predictors of metabolic obesity phenotypes in menopause

Armeni Eleni , Augoulea Areti , Rizos Demetrios , Kaparos George , Soureti Anastasia , Karagouni Iliana , Apostolakis Michail , Lambrinoudaki Irene

Objective: Aiming to identify individuals with more benign metabolic profile, we explored the link between anthropometric predictors as well as serum levels of sex hormones and phenotypes of metabolic health in non-obese postmenopausal women.Methods: A total of 458 non-obese (BMI <30 kg/m2) postmenopausal women (age 55.2±7.1 years, BMI=24.6±2.8 kg/m2) were retrieved from the Menopause Clinic of Aretaieio Hospital, Nati...

ea0049ep1084 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

The effect of hormone replacement therapy and tibolone on lipoprotein (a) concentrations in postmenopausal women: a systematic review and meta-analysis of randomized controlled studies

Anagnostis Panagiotis , Galanis Petros , Chatzistergiou Vasileia , Stevenson John , Godsland Ian , Lambrinoudaki Irene , Theodorou Mamas , Goulis Dimitrios

Introduction: Data on the effect of hormone replacement therapy (HRT) and tibolone on lipoprotein(a) (Lp(a)), an independent risk factor for cardiovascular disease, are heterogeneous and conflicting. The aim of this study was to investigate the effect of HRT and tibolone on Lp(a) concentrations in post-menopausal women.Methods/design: MEDLINE, Scopus, EMBASE and Cochrane databases were searched (up to February 2016). Two researchers identified randomized...

ea0032p207 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Subclinical atherosclerosis and cardiovascular risk in healthy, young menopausal women

Armeni Eleni , Stamatelopoulos Kimon , Georgiopoulos Georgios , Kouskouni Evangelia , Creatsa Maria , Alexandrou Andreas , Papamichael Christos , Lambrinoudaki Irene

Introduction: Delayed diagnosis of a cardiovascular event is related with higher case-fatality rate in women as compared to men. In fact, accumulating evidence supports an association between the menopausal status and the development of cardiovascular disease (CVD). We aimed to assess the extent of subclinical vascular disorders in young, healthy postmenopausal women, with respect to the calculated cardiovascular risk.Methods: This cross-sectional study ...

ea0022p150 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Genetic polymorphisms associated with cardiovascular risk correlate with dyslipidaemia in healthy postmenopausal women

Papadimitriou Dimitra , Kaparos George , Rizos Dimitrios , Armeni Eleni , Creatsa Maria , Alexandrou Andreas , Christodoulakos George , Lambrinoudaki Irene

Objective: To assess the impact of genetic polymorphisms associated with increased cardiovascular risk on the lipid profile in healthy postmenopausal women.Methods: The study population consisted of 84 women between 49–69 years who had been menopausal for at least one year. The genetic polymorphisms examined were the following: Glycoprotein IIIa leu33pro, Apolipoprotein E2/E3/E4, Methylenotetrahydrofolate reductase ala222val, Apolipoprotein B arg350...

ea0022p738 | Steroid metabolism &amp; action | ECE2010

Androgenicity is enhanced in the presence of ala222val polymorphism in healthy postmenopausal women

Papadimitriou Dimitra , Kaparos George , Rizos Dimitrios , Armeni Eleni , Kreatsa Maria , Alexandrou Andreas , Christodoulakos George , Lambrinoudaki Irene

Objective: To assess the interrelation of the MTHFR ala222val polymorphism, correlated with increased rates of cardiovascular disease, with indices of androgenicity in healthy postmenopausal women.Methods: The population of this cross-sectional study consisted of 84 healthy women who had been menopausal for at least one year. The examined polymorphism was Methylenetetrahydrofolate reductase ala222val, while the hormonal assays included Testosterone, Sex ...

ea0073aep90 | Calcium and Bone | ECE2021

Fibrosis 4 score is associated with bone density measures in postmenopausal women

Armeni Eleni , Augoulea Areti , Paschou Stavroula , Palaiologou Anastasia , Kaparos Georgios , Panoulis Konstantinos , Lambrinoudaki Irene

IntroductionThe routine assessment of postmenopausal women involves screening for cardiometabolic risk factors and bone health. Evaluation of the liver function is not commonly performed, even though this could be easily performed with the use of indirect markers, such as the Fibrosis 4 score. Recent evidence supports an association between liver cirrhosis and bone turnover, affecting both the trabecular and the cortical bone. Therefore, we aimed to expl...

ea0067o26 | Oral Presentations | EYES2019

Associations between FSH levels and indices of regional and total obesity in women after menopause

Armeni Eleni , Paschou Stavroula A , Augoulea Areti , Stergiotis Stefanos , Chatzivasiliou Panagiota , Rizos Dimitrios , Kaparos George , Panoulis Konstantinos , Palaiologou Anastasia , Lambrinoudaki Irene

Objective: Recent evidence reports a controversial extra-gonadal role of follicle stimulating hormone (FSH). Conflicting data support that the association between FSH and obesity might be maintained by a direct or even indirect effect to the adipose tissue. The aim of this study was to evaluate the associations between FSH concentrations and various obesity indices in women after menopause.Methods: This cross-sectional study included 420 postmenopausal w...