Endocrine Abstracts

Introduction: The development of molecular biology and cancer immunology has brought drastic changes in anticancer in recent years. Recently, tyrosine kinase inhibitors (TKI) and immune checkpoint inhibitors (ICPIs) have emerged as new classes of anticancer therapies. Although generally considered less toxic than cytotoxic chemotherapy, these new drugs can cause significant side effects including thyroid dysfunction. We report the case of thyroiditis induced by Pembrolizumab (...

Introduction: Celiac disease is an autoimmune disorder related to gluten ingestion in genetically predisposed individuals. Its clinical expression is polymorphic, rendering it a true systemic disease, and its management is based on a gluten-free diet (GFD). Autoimmune endocrinopathies are disorders affecting endocrine glands such as the thyroid or adrenal glands, also stemming from autoimmune reactions with complex pathophysiological mechanisms involving environmental, genetic...

Introduction: Brown tumors are osteolytic lesions rarely revealing hyperparathyroidism. They result from abnormalities of bone metabolism. They usually occur in the terminal stage of hyperparathyroidism. We report the case of a patient with hyperparathyroidism revealed by a brown tumor.Case: A 39-year-old female patient with no notable medical history who presented for 1 year a mandibular swelling progressively increasing in size after a dental extractio...

Introduction: Primary hyperparathyroidism (PPH) can be complicated by pancreatitis. The frequency of association of primary hyperparathyroidism with pancreatitis is rare, varying between 1.5% and 7%. We report the case of a patient with hyperparathyroidism revealed by acute pancreatitis.Case: A 78-year-old patient, without any particular history, who consulted the emergency room for an acute digestive picture with abdominal pain and bilious vomiting, an ...

Introduction: Primary hyperparathyroidism is a common pathology. The association of papillary thyroid carcinoma and primary hyperparathyroidism has been reported in 2.3–4.3% of patients operated on for primary hyperparathyroidism.We report the case of a patient with papillary thyroid carcinoma revealed by primary hyperparathyroidismObservation: 53-year-old patient admitted for management of primary hyperparathyroidism. A cervical ultrasound revealed...

Introduction: Parkinson’s disease is considered the most common chronic neurodegenerative disease that often affects the elderly, rarely the young. Meanwhile, Diabetes mellitus is the most common chronic metabolic disease. Because of the increase in the prevalence of diabetes and neuro-vegetative diseases, we can wonder about the relationship between the two diseases. We report the case of a patient with type 2 diabetes mellitus associated with young onset Parkinson’...

Introduction: Fournier’s gangrene (FG) is a rare but life-threatening disease. Although originally thought to be an idiopathic process, FG has been shown to have a predilection for patients with diabetes, HIV, alcoholism and other immunocompromised states. We report the case of a patient who presented an inaugural diabetic ketoacidosis revealed by Fournier’s gangreneObservation: A 38-year-old male patient with a smoking history, presented to th...

Introduction: Familial hypercholesterolemia is an autosomal dominant genetic disease linked to a mutation in 3 genes involved in the catabolism of LDL particles. It is characterized by an exclusive increase in low-density lipoproteins (LDL). It is associated with a high risk of premature cardiovascular complications. We report the case of a patient with familial hypercholesterolemia.Case: 44-year-old patient, From a first-degree consanguineous marriage, ...

Introduction: Pheochromocytoma is a rare neuroendocrine tumor. It is usually diagnosed in subjects between 40 and 50 years of age. The occurrence of pheochromocytoma in the elderly is much rarer and has its own particularities. We report the case of a 70-year-old female patient with invasive pheochromocytoma.Case presentation: A 70-year-old female patient with a history type 2 diabetes for 18 years on oral antidiabetics and insulin. The history of his di...

Introduction: Hypercalcemia is often observed in patients with cancer, secondary to the production s of parathyroid hormone (PTH)-related peptides. However, the association of primary hyperparathyroidism (pHPT) and colon cancer is rarely reported.Case: We present the case of a 76 years old female patient, who was operated one year ago of for a low-grade colorectal adenocarcinoma. As part of her routine workup of her disease she underwent a phosphocalcic ...