Searchable abstracts of presentations at key conferences in endocrinology

ea0025p334 | Thyroid | SFEBES2011

Depot specific differences in regulation of hyaluronan production of relevance to Graves’ orbitopathy

Zhang Lei , Grennan-Jones Fiona , Lane Carol , Rees D Aled , Dayan Colin , Ludgate Marian

Expansion of the orbital contents, by adipogenesis and hyaluronan (HA) overproduction, causes Graves orbitopathy (GO). Orbital HA is generated predominantly by hyaluronan synthase 2 (HAS2) whose transcription is positively regulated by pAkt in cell lines. GO is most frequently associated with Graves’ disease (GD) in which thyroid stimulating antibodies bind the TSH receptor (TSHR) increasing cAMP. Previous studies highlight a role for TSAB and ‘neutral’ TSHR ant...