Searchable abstracts of presentations at key conferences in endocrinology

ea0028p322 | Steroids | SFEBES2012

Modified-release prednisolone increases quality of life compared to standard prednisolone in patients with adrenal insufficiency

Quinkler Marcus , Ventz Manfred , Hinz Andreas , Langenheim Jorinde

Context: Patients with adrenal insufficiency (AI) receive glucocorticoid replacement therapy, which tries to imitate physiological adrenal secretion. However, the first glucocorticoid dose is usually given after waking in the morning resulting in a 3–5 h delay compared to physiological secretion. Impaired quality of life (QoL) might be, in part, due to this delayed dose scheme. Therefore, modified-release glucocorticoid preparations might have therapeutical advantages.</p...