Searchable abstracts of presentations at key conferences in endocrinology

ea0089b4 | Basic Science | NANETS2022

Simultaneous Inhibition of DNA Methylation and Histone De-acetylation for Enhanced SSTR2 Expression In Vitro

Whitt Jason , Houson Hailey , Guenter Rachael , Murphy Madisen , Lapi Suzanne , Jaskula-Sztul Renata

Background: Neuroendocrine tumor (NET) patients with diminished SSTR2 expre-ssion are not eligible for any type of SSTR2-specific imaging or treatment. Herein, we propose to epigenetically enhance and enable somatostatin receptor type 2 (SSTR2)-targeted theranostics for patients with NETs. Specifically, we have found that simultaneous inhibition of DNA methylation and his-tone de-ace-tylation enhanced SSTR2 expression and in vitro binding of [68Ga]DOTATATE....

ea0098b11 | Basic Science | NANETS2023

The Notch1 pathway is a critical regulator of SSTR2 expression in neuroendocrine tumors

Guenter Rachael , Whitt Jason , Chen Weisheng , Houson Hailey , Bart Rose J. , Chen Herbert , Lapi Suzanne , Jaskula-Sztul Renata

Background: Patients with neuroendocrine tumors (NETs) have a 5-year survival rate of 30-60%. Surgery, and newly approved ‘tar-geted radionuclide therapy (TRT)’ with [177Lu]DOTATATE, are the only curative options for patients with NETs. TRT is limited to pa--tients that have high levels of somatostatin receptor subtype 2 (SSTR2) and can im-prove the survival of patients with low-grade tumors, but has little effect on high-grade NETs that express low SSTR2 ...

ea0089b6 | Basic Science | NANETS2022

Detecting Cell Surface Expression of Calreticulin in Pancreatic Neuroendocrine Tumors Using a Novel [68Ga]-Radiolabeled Peptide

Guenter Rachael , Ducharme Maxwell , Herring Brendon , Montes Odalyz , McCaw Tyler , Lee Goo , Dhall Deepti , MacVicar Caroline , Chen Herbert , Lapi Suzanne E. , Larimer Benjamin , Bart Rose J.

Background: Current theragnostic techniques for pancreatic neuroendocrine tumors (pNETs) exploit the overexpression of somatostatin receptors (SSTRs) on the cell surface. However, approximately 25% of low-grade and most high-grade pNETs do not express SSTRs, requiring alternative theranostics. Calreticulin (CALR) is a protein linked to reticular calcium homeostasis and immunogenic cell death. Upon sufficient cellular insult, CALR translocates from the endoplasmic reticulum (ER...