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Endocrine Abstracts

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ea0081p15 | Adrenal and Cardiovascular Endocrinology | ECE2022

Decreased steroidogenic enzymes activity in benign adrenocortical tumors is more pronounced in bilateral lesions as determined by steroid profiling in HPLC-MSMS during ACTH stimulation test

Fideline Bonnet , Barat Maxime , Vaczlavik Anna , Jouinot Anne , Bouys Lucas , Laguillier-Morizot Christelle , Zientek Corinne , See Catherine , Larger Etienne , Guignat Laurence , Groussin Lionel , Assie Guillaume , Guibourdenche Jean , Nicolis Ioannis , Menet Marie-Claude , Bertherat Jerome

Objective: Large response of steroids precursors, including 17-hydroxyprogesterone and 11-deoxycortisol, to ACTH has been described in adrenocortical tumors, suggesting the existence of intra-tumoral enzymatic deficiencies. This study aimed to compare steroidogenic enzymes activity in unilateral and bilateral benign tumors using serum steroid profiling in HPLC-MS/MS in basal state and after ACTH 1-24 stimulation.Design and Methods: A serum profile of sev...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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