ea0101ps1-01-01 | Autoimmunity | ETA2024
Galgoczi Erika
, Orsos Istvan
, Molnar Zsanett
, Ujhelyi Bernadett
, Steiber Zita
, Szabo Laszlo
, Dienes Beatrix
, Csernoch Laszlo
, Nagy Endre V.
, Katko Monika
Introduction: In the pathogenesis of thyroid eye disease (TED) activated fibroblasts in the orbital connective tissue show increased proliferation, hyaluronan (HA) production, and adipogenic differentiation potential. As a result of these, the orbital tissue volume expands and the intraorbital pressure increases. Mechanical stimuli, including high intraorbital pressure, may lead to the activation of mechanosensitive receptors, such as Piezo1, whose presence in orbital fibrobla...