Searchable abstracts of presentations at key conferences in endocrinology

ea0101ps1-01-01 | Autoimmunity | ETA2024

Modelling of mechanical stimuli through piezo1 receptor activation and its effect on adipogenic differentiation of orbital fibroblasts

Galgoczi Erika , Orsos Istvan , Molnar Zsanett , Ujhelyi Bernadett , Steiber Zita , Szabo Laszlo , Dienes Beatrix , Csernoch Laszlo , Nagy Endre V. , Katko Monika

Introduction: In the pathogenesis of thyroid eye disease (TED) activated fibroblasts in the orbital connective tissue show increased proliferation, hyaluronan (HA) production, and adipogenic differentiation potential. As a result of these, the orbital tissue volume expands and the intraorbital pressure increases. Mechanical stimuli, including high intraorbital pressure, may lead to the activation of mechanosensitive receptors, such as Piezo1, whose presence in orbital fibrobla...