Endocrine Abstracts

The androgen receptor (AR) signaling pathway is central to the emergence of castration-resistant prostate cancer (CRPC). miR-32 is an androgen regulated miRNA which is differentially expressed in CRPC compared to benign prostatic hyperplasia (BPH) and able to provide a significant growth advantage to LNCaP cells. To study how increased miR-32 expression contributes to prostate cancer formation and/or progression in vivo, we have established transgenic mice expressing ...

Prostate cancer is multifocal in nature, and histological grading is the key clinical prognostic factor. To build non-subjective histological analysis tools, and to model the multifocality of prostate cancer within the organ, we use analysis of histological images to quantitatively describe prostate cancer. Our current effort shows how heterogeneity in prostate tissue due to cancer or spatial location can be quantified with image-derived features. We use high-resolution digita...