Searchable abstracts of presentations at key conferences in endocrinology

ea0092ps2-16-07 | Thyroid Cancer clinical 2 | ETA2023

Tumor lysis syndrome during neoadjuvant selpercatinib treatment for medullary thyroid cancer

Trevisan Matteo , De Leo Simone , Vanessa Re Sarto Giulia , Moneta Claudia , Pirovano Marta , Colombo Carla , Cosmai Laura , Fugazzola Laura

Selpercatinib is a specific RET inhibitor, highly effective in the treatment of advanced RET-mutant medullary thyroid carcinoma (MTC). The consequences of selpercatinib administration in MTC patients who have not undergone thyroid surgery are still unknown. We report the case of an 84-year-old man undergoing investigations for worsening diarrhea and weight loss. Upon a neck ultrasound scan and blood exams that pointed out high levels of both calcitonin (CT, 20.583 ng/l) and ca...

ea0063s1.1 | Thyroid in cancer | ECE2019

What is the value of molecular markers in nodules?

Fugazzola Laura

Cytological evaluation establishes the diagnosis of a benign or malignant nodule in 70–80% of all cases, but the remaining cases lack the features needed for a definitive diagnosis. Molecular tests have been developed to assist in determining if a nodule with indeterminate cytology is benign or malignant. The first studies focused on the analysis of the most common thyroid cancer (TC) mutation, BRAFV600E. However, since many TCs are driven by other mutations, testing for ...

ea0032s29.1 | Management of thyroid nodules | ECE2013

Molecular analysis of FNAB material

Fugazzola Laura

The evaluation of a thyroid nodule is a very common clinical problem and fine needle aspiration biopsy (FNAB) is the only test that can provide a definitive preoperative diagnosis of malignancy. The sensitivity and specificity of FNAB are limited by aspirates that yield insufficient material for definitive diagnosis and those with indeterminate diagnoses, which can account for up to 30–40% of all specimens. The detection of several novel gene mutations in differentiated t...

ea0084ps1-04-32 | Thyroid Hormone Transporters and Development | ETA2022

Three-dimensional spheroids: a new approach for the identification and characterization of novel markers for tumor-initiating cells subpopulations in thyroid cancer

Ghiandai Viola , Stellaria Grassi Elisa , Fugazzola Laura , Persani Luca

Thyroid cancer (TC) is the most common endocrine malignancy, with an increasing number of diagnosis in the last decades. Of all TC histotypes, the poorly differentiated and anaplastic TCs (PDTC and ATC) have a very poor prognosis because of their invasiveness and metastatic behavior, as well as their insensitivity to radioactive-iodine treatment. In the last years, the stem-cell model has been proposed to further explain TC carcinogenesis. According to this model, only a subse...

ea0084ps2-08-68 | Thyroid Cancer BASIC | ETA2022

NOX-derived oxidative stress is high in neoplastic thyroid lesions and correlates with ata risk in papillary thyroid cancer

Pogliaghi Gabriele , Muzza Marina , Colombo Carla , Persani Luca , Fugazzola Laura

Oxidative stress (OS) can have an impact both in the pathogenesis and in the progression of TC, as it has been shown to induce oncogenes and inhibit tumor suppressors. The main source of cellular ROS is represented by NADPH oxidases (NOXs). Aims of the study were to investigate the NOX-derived OS in TC samples, benign nodules and corresponding normal tissues, and to correlate the level of OS with histological classification, genetic profile and clinical and prognostic features...

ea0084ps2-08-72 | Thyroid Cancer BASIC | ETA2022

The extracellular matrix actively influence thyroid cancer cells sensitivity to TKIS

Stellaria Grassi Elisa , Ghiandai Viola , Fugazzola Laura , Persani Luca

Thyroid cancer (TC) is the most common endocrine tumor and its incidence has increased faster than in any other malignancy. Although TCs are usually well differentiated, disease recurrence or persistence is high, because of local and distant metastasis and therapeutic resistance. As in other cancer types, despite the promising results obtained in pre-clinical studies, the efficacy of Targeted Therapy is highly variable and therapy resistance is not uncommon. This may be due to...

ea0041gp228 | Thyroid Cancer | ECE2016

Genetic heterogeneity of thyroid cancer

Colombo Carla , Perrino Michela , Muzza Marina , Cirello Valentina , Fugazzola Laura

There are growing evidences suggesting the existence of intra-tumor heterogeneity within the same patient, leading to a different genetic pattern between primary tumour and metastases.We report a paradigmatic example of genetic heterogeneity in thyroid cancer (TC). A 42 years old female patient was submitted, for a follicular TC, to total thyroidectomy and lymphadenectomy followed by radioiodine residue ablation in late 1999. In 2000 and 2001 diagnostic ...

ea0092op-03-05 | Oral Session 3: Signalling in Thyroid cancer | ETA2023

From nucleus to mitochondria: insights into the role of tert in aggressive papillary thyroid carcinomas

Pogliaghi Gabriele , Muzza Marina , Grassi Elisa , Persani Luca , Fugazzola Laura

TERT is the protein component of the telomerase enzyme and is overexpressed in many cancer types. The most well-known role for TERT is the regeneration of telomeres allowing the avoidance of senescence and the continued proliferation of stem and cancer cells. Recent studies have identified other roles for TERT in compartments outside the nucleus, in particular in mitochondria, with a protective role against endogenous and therapy-induced oxidative stress (OS). A small subset o...

ea0092ps2-19-05 | Thyroid Hormone Transport & Metabolism Basic | ETA2023

Characterization of epcam in thyroid cancer biology by three-dimensional spheroids in vitro model

Ghiandai Viola , Stellaria Grassi Elisa , Fugazzola Laura , Persani Luca

Thyroid cancer (TC) is the most common Endocrine malignancy. Nowadays Undifferentiated Thyroid Cancers (UTCs) are still a lethal disease, mostly because of the lack of effective therapeutic options. The insurgence of therapy resistance and disease relapse is believed to be caused by a subpopulation of cancer cells with a stem-like phenotype and specific tumor-initiating abilities, the so called Tumor-Initiating Cells (TICs). Several markers have been identified and described o...

ea0081rc11.3 | Rapid Communications 11: Thyroid 2 | ECE2022

Is the pre-conceptional TSH optimization useful in women submitted to assisted reproduction technology?

Maria Vannucchi Guia , Campi Irene , Cagnina Serena , Covelli Danila , Persani Luca , Mignini Renzini Mario , Fugazzola Laura

Background: thyroid function (TSH levels) and thyroid autoimmunity are involved in the immunomodulation of early pregnancy stages and can affect assisted reproductive technology (ART).Aims: 1) to evaluate if pre-conceptional TSH is associated with an increased risk of miscarriage, 2) to identify a TSH cut-off significantly associated with risk of miscarriage, 3) to assess the impact of TSH levels on primary and surrogate outcomes.M...