Searchable abstracts of presentations at key conferences in endocrinology

ea0032p93 | Bone and Osteoporosis | ECE2013

Age overlooked as a risk factors for osteoporosis

Andersen Stig , Nielsen Ole , Laurberg Peter

Osteoporosis is a debilitating condition that can be prevented by timely detection and treatment. Detection requires referral for dual energy X-ray absorptiometry (DXA) that depends on risk factors. We estimated the importance of risk factors for a T-score of <−2.5 measured by spine and hip DXA in all men and women referred from general practice for a DXA scan at Aalborg University Hospital during a 3 years period. Risk factors were assessed by questionnaire...

ea0014p604 | (1) | ECE2007

Excess mortality in women with pituitary disease: results of a meta-analysis

Husted Nielsen Eigil , Lindholm Jörgen , Laurberg Peter

Background: Several studies of rather heterogeneous groups of patients have shown an increased mortality in patients with pituitary diseases. In patients without hypersecretion of growth hormone or ACTH the increased mortality has mostly been attributed to pituitary insufficiency. Some studies have suggested sex-specific differences in standard mortality rates (SMR) whereas others have shown increased cardiovascular and/or cerebrovascular mortality. A recent study of patients ...

ea0035p673 | Growth hormone IGF axis basic | ECE2014

Incidence and late prognosis of acromegaly in Denmark: preliminary data

Dal Jakob , Feldt-Rasmussen Ulla , Andersen Marianne , Kristensen Lars , Laurberg Peter , Sorensen Henrik , Jorgensen Jens Otto

Introduction: Acromegaly is a rare disease caused by GH hypersecretion from a pituitary adenoma. However, accurate estimates of incidence and prevalence are scarce and not based on nationwide populations. It is well known that surgical cure may normalize mortality and improve morbidity but similar data are not available for patients receiving medical treatment.Method: We first validated the ICD-8 and ICD-10 diagnosis codes for acromegaly in The National ...

ea0032p849 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

The prevalence of insufficient test responses in patients with traumatic brain injury compared to healthy controls – results from The Danish National Study on posttraumatic hypopituitarism

Klose Marianne , Laurberg Peter , Frederiksen Louise , Stochholm Kirstine , Janukonyte Jurgita , Christiansen Jens Sandahl , Andersen Marianne , Feldt-Rasmussen Ulla

Introduction: We questioned the justification of general recommendations for assessment of hypopituitarism in patients with traumatic brain injury (TBI), and aimed to describe the prevalence of hypopituitarism in a national TBI population of patients admitted to a Danish hospital in 2008, as compared to healthy controls.Patients and methods: We included 463 patients (18–65 years) hospitalized ≥24 h, with more than subtle TBI as indicated by lo...

ea0032p1014 | Thyroid (non-cancer) | ECE2013

Biochemical testing on wide indication to detect overt hypothyroidism is justified: a population-based case–control study in patients newly diagnosed with overt autoimmune hypothyroidism

Carle Allan , Pedersen Inge Bulow , Knudsen Nils , Ovesen Lars , Rasmussen Lone Banke , Jorgensen Torben , Perrild Hans , Laurberg Peter

Objectives: Hypothyroid patients report a diversity of symptoms at disease presentation. We studied how useful symptoms are to predict hypothyroidism, and if this may vary between subgroups of patients.Methods: Patients newly diagnosed with overt autoimmune hypothyroidism (n=140) were prospectively identified in a population by linkage to diagnostic laboratory databases, and we concomitantly enrolled individually sex and age-region matched contr...

ea0026p268 | Pituitary | ECE2011

Frequency of acute-onset symptoms and other features of craniopharyngioma presentation in children and adults

Nielsen E H , Jorgensen J O , Bjerre P , Andersen M , Andersen C , Feldt-Rasmussen U , Poulsgaard L , Kristensen L O , Astrup Jens , Lindholm Jorgen , Laurberg Peter

Introduction: Clinical symptoms in craniopharyngioma have been repeatedly described in the literature, but few studies have addressed the issue of acute-onset symptoms in children or adults. Refinements of diagnostic procedures and altered scanning routines over the last two decades may in theory have affected patterns of clinical presentation.Objective: To study the clinical phenotype of patients with newly diagnosed craniopharyngioma, with focus on var...

ea0022p617 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Epidemiology of craniopharyngioma in Denmark 1985–2004: a 2% increase in incidence rate per year

Husted Nielsen Eigil , Feldt-Rasmussen Ulla , Poulsgaard Lars , Ostergaard Kristensen Lars , Astrup Jens , Otto Jorgensen Jens , Bjerre Per , Andersen Marianne , Andersen Claus , Jorgensen Jesper , Lindholm Jorgen , Laurberg Peter

Background: Craniopharyngioma may be associated with severe morbidity. Few data exist on incidence rate (IR) and possible changes with time. The epidemiology of craniopharyngioma in Denmark has never been evaluated in detail.Objectives: To review the literature on craniopharyngioma incidence and to study the epidemiology of craniopharyngioma in Denmark during a recent 20-year period.Material and methods: Publications including data...

ea0021p280 | Pituitary | SFEBES2009

Treatment experience in 11 patients with gigantism

Higham Claire E , Emy Phillipe , Ferone Diego , Finke Reinhard , Laurberg Peter , Main Katharina , Maffei P , Martini C , Minuto Francesco , Rainegard Isabelle , Salzgeber Kirsten , Vogel C , Koltowska-Haggstrom Maria , Trainer Peter J

Gigantism is an extremely rare condition and hence the relevant literature is largely a series of case reports. We present data on patients with gigantism <20 years of age identified from Pfizer’s Acrostudy registry of patients treated with pegvisomant.Eleven patients (5M) were identified: IGF1 at diagnosis was 1.6×ULN (1.15–3.3), height +5 SDS (1.1–3.8) and age 14.5 years (4–19). The three youngest (4, 7 and 14 years) had pi...

ea0025oc3.8 | Pituitary and thyroid | SFEBES2011

Assessment of the UK iodine status: a National Survey

Vanderpump Mark , Lazarus John , Smyth Peter , Burns Robert , Eggo Margaret , Han Thang , Williams Graham , Torlinska Barbara , Mullan Karen , Pearce Simon , Razvi Salman , Lean Mike , Aspray Emile Combet , Bannon Denise , Abraham Prakash , Vadia Bijay , Leese Graham , Laurberg Peter , Boelaert Kristien , Franklyn Jayne

Inadequate dietary iodine intake is the most common cause of preventable mental impairment worldwide and is defined by the WHO as a population median urinary iodine (UI) excretion <100 μg/l. No contemporary data are available for the UK according to the ICCIDD. The UK has no programme of food/salt iodination.We have performed a systematic assessment of the current UK iodine status in 14–15 years old schoolgirls. Seven hundred and eighty-fiv...