ea0059oc6.4 | Neuroendocrinology and Reproduction | SFEBES2018
Owens Lisa
, Abbara Ali
, Lerner Avi
, Christopoulous Georgios
, Lavery Stuary
, Hardy Kate
, Dhillo Waljit
, Hanyaloglu Aylin
, Franks Stephen
Background: Kisspeptin stimulates gonadotropin secretion indirectly by stimulation of hypothalamic GnRH neurons. Kisspeptin and kisspeptin receptor, a G-protein coupled receptor (GPCR), are also expressed in the human ovary, but their direct actions on ovary, if any, are unclear.Objectives: To examine the direct actions of kisspeptin on granulosa lutein cells (GL cells) and the role of kisspeptin in steroidogenesis.Materials and me...