Searchable abstracts of presentations at key conferences in endocrinology

ea0023p4 | (1) | BSPED2009

Use of clinic proforma as a tool has been shown to improve diabetic reviews

Law James , Thomas Dougie

Acute and long-term complications attributable to diabetes are regrettably still common. To monitor for the development of such complications NICE recommend regular measurement of certain criteria to enable early intervention. A previous audit performed in our hospital looked at the adherence of paediatric diabetic reviews to NICE guidelines. As a consequence of this audit a detailed pro-forma to be used at all paediatric diabetic reviews was introduced....

ea0066oc5.8 | Oral Communications 5 | BSPED2019

TSH-Receptor testing in pregnancy allows stratification of risk of neonatal thyrotoxicosis and promotes earlier discharge

Law James , Chauhan Hemma , Wynn-Davies Anneli

Background: Local guidelines for infants born to mothers with a history of thyrotoxicosis previously recommended that infants were observed in hospital until thyroid function tests were checked on day 4, with follow up on day 10, causing inconvenience to families and unnecessary cost to services. Following a literature search, our revised local guidelines recommend low-risk infants can be discharged on day 0 without follow up, stratified using maternal TSH-receptor antibody (T...

ea0051p006 | Thyroid | BSPED2017

Routine checking of TSH-receptor Antibodies in pregnancy to reduce postnatal length of stay

Law James , Fozi Anis Mohd , Wynn-Davies Anneli

Introduction: Graves’ hyperthyroidism affects 0.2–2% of women and 1–5% of infants born to these mothers will be symptomatic. Neonatal thyrotoxicosis is a potentially life-threatening condition and infants are currently monitored in hospital till day 4 of life. Graves’ disease is caused by TSH-receptor antibodies (TRAb) which can cross from the maternal to the foetal circulation where they may stimulate the developing thyroid gland causing neonatal thyrotoxi...

ea0066p38 | Diabetes 3 | BSPED2019

Remission rates, demographics and outcomes of paediatric patients with type 2 diabetes at a single centre: 2006–2018

Procter Elizabeth , Law James , Calvert Jennifer , Sachdev Pooja

Background: Incidence of type 2 diabetes (T2DM) is increasing in children and young people under the age of 18 years. This group has a higher risk of microvascular complications and a more adverse cardiovascular risk profile than those diagnosed later. Weight loss is essential for remission, but intensive input is often required to achieve this.Aims: 1. Describe the demographics of our T2DM population2. Look at our remission rates<...

ea0085p10 | Bone | BSPED2022

Hypophosphatemic rickets as a key presenting feature of tyrosinemia type 1

Chandwani Manju , Usman Shehla , Law James , Denvir Louise , Sachdev Pooja , Randell Tabitha , Qureshi Isaque

Queen’s Medical Centre, Nottingham, United KingdomTyrosinemia type-1 is a rare autosomal recessive disorder. It usually presents in an acute form in early infancy. Rarely, it can also present as a chronic form with gradual onset. The key presenting features are failure to thrive, liver dysfunction and/or Fanconi syndrome. We present a perplexing case of a 2-year-old girl with tyrosinemia type-1, who initially presented with failure to thrive and hypophosphatemic rickets w...

ea0066oc8.3 | Oral Communications 8 | BSPED2019

Specially identified patients (SIPs) – how do they work?

Rajyaguru Vipul , Tan Shin , Law James , Sachdev Pooja , Denvir Louise , Randell Tabitha

Introduction: Children with adrenal insufficiency require emergency hydrocortisone for serious illness in addition to any regular requirements. Individualised emergency plans for patients during sick days, detailing their oral and intramuscular hydrocortisone requirements, should be maintained, alongside appropriate alerts on hospital and pre-hospital systems to ensure health professionals are aware of their requirements promptly if they present acutely unwell. Following a chi...

ea0066p49 | Diabetes 5 | BSPED2019

Paediatric random glucose requests in primary care

Nicholson Benjamin , Smith Karen , Law James , Randell Tabitha , Denvir Louise , Sachdev Pooja

Background: NICE guidelines (NG18) state that paediatric patients aged <18 years old with suspected diabetes mellitus (DM) should be immediately referred to specialist care to confirm diagnosis and provide immediate treatment. The Nottingham University Hospitals (NUH) Paediatric Endocrine team advise primary care to investigate suspected hyperglycaemia using a POCT (point of care testing) glucose meter at the primary care facility to avoid the delay incurred by sending a s...

ea0039ep31 | Diabetes | BSPED2015

Comparison of current trends in obesity in patients with type 1 diabetes in Nottingham with a historical cohort and 2013–2014 national child measurement programme data in the UK

Mohamed Zainaba , Law James , Denvir Louise , Chee Carolyn , Drew Josaphine , Sachdev Pooja , Randell Tabitha

Aim: To compare the BMI z-score of children with type 1 diabetes (T1DM) in Nottingham with that of national and local background populations and to identify factors associated with increased BMI.Methods: A retrospective observational cohort study of patients with T1DM aged 2–15 years under the care of the paediatric diabetes team at Nottingham Children’s Hospital, between April 2013 and March 2014. Mean BMI-z-score for the year was com...

ea0038p219 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

Non-selective beta-adrenergic agonist infusion acutely stimulates the temperature of brown adipose tissue in adult males

Scotney Hannah , Symonds Michael , Law James , Budge Helen , Sharkey Don , Manolopoulos Konstantinos

Brown adipose tissue (BAT) is present in small quantities in human adults (~100 g) and can have a significant influence on metabolism. This effect is mediated by rapid activation of the BAT specific uncoupling protein 1 (UCP1), following stimulation of β-adrenergic receptor (AR) by the sympathetic nervous system. AR agonists stimulate rodent BAT, but have so far provided inconsistent findings in humans when administered orally (Vosselman et al. 2012). Rapid activ...

ea0058p013 | Gonadal | BSPED2018

Pubertal induction among girls with turner syndrome: an audit of practice from 2008–2017

Elechi Hassan Abdullahi , Law James , Benson Joanna , Dever Louise , Randell Tabitha , Sachdev Pooja

Background: Pubertal induction with incremental doses of oestrogen replacement is an important component of care offered to hypogonadal patients with Turner Syndrome (TS). Low dose oral ethinylestradiol (EE) has been extensively used in the UK but natural 17-β oestradiol (more physiological, cheaper and easily monitored in blood) is becoming increasingly popular. We undertook this audit to compare the efficacy and acceptability of oral (EE) and patch (Evorel) oestrogen pr...