Searchable abstracts of presentations at key conferences in endocrinology

ea0081p528 | Adrenal and Cardiovascular Endocrinology | ECE2022

The role of neuropeptide Y in the pathogenesis of vasovagal syncope

Lazurova Zora , Lazurova Ivica , Mitro Peter , Popovnakova Marcela

Introduction: Vasovagal syncope (VVS) is a transient loss of conscioussness due to hypoperfusion of the brain caused by vasodepressoric and/or cardioinhibitory reflex. In the pathogenesis, a dysregulation of autonomic nervous system is playing an important role. There is a growing evidence about more complex neurohumoral background of VVS. Neuropeptide Y (NPY) is hormone involved in the regulation of blood pressure with potent vasoconstriction effect. Moreover, NPY is also a c...

ea0099ep928 | Pituitary and Neuroendocrinology | ECE2024

A rare case of transient central hypothyroidism

Lazurova Zora , Semancik Juraj , Javorsky Martin

We report a case of 48 years old female with history of arterial hypertension and breast cancer in long term remission. She was admitted to the hospital due to strong headache. MRI of the brain revealed spontaneous intracranial hypotension caused by the cerebrospinal fluid (CSF) leak in left fronto-parietal region, thickening of pachymeningeal tissues, distension of sinus transvs and cranial buldging of the pituitary gland with non homogenous structure. Although patient did no...

ea0041gp179 | Reproduction & Endocrine Disruption | ECE2016

Urinary bisphenol A in PCOS women and its relation to steroid hormones

Lazurova Zora , Hubkova Beata , Marekova Maria , Figurova Jana , Lazurova Ivica

Bisphenol A (BPA) is an environmental estrogen found in plastic material such as bottles, food package, dental material, etc. It is known to have many negative effects on human health and its exposure is associated with endocrine disorders including polycystic ovary syndrome (PCOS). Some studies found significantly higher serum and urinary levels of BPA in PCOS women, however its association with steroid hormones is still controversial.Aim: The aim of th...

ea0056p906 | Endocrine Disruptors | ECE2018

Relationship of urinary bisphenol A to metabolic and hormonal profile in PCOS women

Lazurova Zora , Figurova Jana , Hubkova Beata , Lazurova Ivica

Objectives: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women. Its increasing prevalence is probably related to environmental estrogens exposure, such as bisphenol A (BPA). BPA is considered to play an important role in the ethiopathogenesis of PCOS and can be responsible for various clinical symptoms. Aim of the study was to compare the levels of urinary BPA between PCOS women and healthy controls and to assess the relationship of BPA to sex...

ea0063p1030 | Interdisciplinary Endocrinology 2 | ECE2019

The role of adenosinergic system in patients with orthostatic intolerance

Lazurova Zora , Mitro Peter , Jakubova Marta , Simurda Milos , Durovcova Eva , Popovnakova Marcela

Objectives: Adenosine is a purinergic mediator involved in the regulation of many physiological and pathological processes. It acts as neurotransmitter in the central and autonomic nervous system, where it counterbalanaces sympathetic activity. Adenosine is produced by majority of human cellsexerting autocrine, paracrine as well as systemic effects. Due toits vasodilatatory and negative inotropic effects it seems to play a role in ethiopathogenesis of orthostatic intolerance, ...

ea0049ep1127 | Female Reproduction | ECE2017

Relationship between steroid hormones and metabolic profile in women with polycystic ovary syndrome

Lazurova Zora , Figurova Jana , Ujhazi Simona , Mašlankova Jana , Toporcerova Silvia , Lazurova Ivica

Background: There is evidence that polycystic ovary syndrome (PCOS) is commonly associated with higher cardiometabolic risk. Aim of the study was to compare various sex streoids in PCOS women with overweight or obesity (BMI >27) and those with lower BMI. Second aim of the study was to determine the relationship of various sexual setroids to cardiovascular risk in PCOS women.Subjects and methods: Study included 64 Caucasian women with PCOS. F...

ea0070aep811 | Reproductive and Developmental Endocrinology | ECE2020

Urinary bisphenol A (BPA) and its relation to insulin growth factor (IGF) system in polycystic ovary syndrome

Lazúrová Ivica , Lazurova Zora , Figurová Jana , Hubkova Beata , Mareková Maria

Objectives: There is a growing evidence suggesting an impact of endocrine distrupting chemicals, including bisphenol A (BPA) on human reproduction. Insulin growth factors (IGF) play signifcant role inhuman reproduction. However the relationship between BPA and IGF system is unknown. Aim of the pilot study was to assessthe relationship between urinary BPA (U-BPA) and insulin growth factors (IGF-1, IGF-2, IGFBP 3) as well as metabolic parametersin PCOS women.<p class="a...

ea0056p926 | Female Reproduction | ECE2018

Polycystic ovary syndrome and insulin-like growth factor (IGF) system.

Lazurova Ivica , Figurova Jana , Lazurova Zora , Toporcerova Silvia , Rabajdova Miroslava , Maslankova Jana

Objectives: Insulin-like growth factors 1 and 2 (IGF1 and IGF2) are widely expressed mitogenic peptides playing a role in the fetal developement and differentiation. Evidence suggest their possible involvement in the pathogenesis of metabolic syndrome and probably in polycystic ovary syndrome (PCOS).Aim: Aim of the study was to assess the relationship of serum IGF1, IGF2 and IGF binding protein 3 (IGFBP3) levels to steroid hormones and metabolic paramete...

ea0099p437 | Adrenal and Cardiovascular Endocrinology | ECE2024

Adrenocortical activity in patients with vasovagal syncope

Bačkorova Barbora , Lazurova Zora , Lukačova Monika , Mitro Peter , Lazurova Ivica

Background: Syncope is a transient loss of consciousness resulting from cerebral hypoperfusion. Despite the extensive efforts by the scientific community over decades, the pathophysiology remains unclear. Although syncope itself is a reversible, short-lasting, benign condition, it negatively impacts quality of life. Vasovagal syncope (VVS) is a form of orthostatic intolerance (OI). Its clinical signs such as dizziness and hypotension may mimic symptoms of adrenal insufficiency...