Searchable abstracts of presentations at key conferences in endocrinology

ea0019oc16 | Neuroendocrine and Steroids | SFEBES2009

Immunohistochemical evidence that Argillin, the product of the ECRG4 gene, encodes a novel neuroendocrine peptide

Roberton A , Gonzalez AM , Stopa E , Leadbeater W , Coimbra R , Johanson C , Eliceiri B , Baird A

Genes that encode neuropeptides can be recognized in the human genome because their products are (1) highly conserved across species, (2) trafficked though cells by secretory signal peptides and (3) susceptible to proteolytic cleavage at consensus sequences for processing to neuroactive products. One candidate gene is oesophageal cancer-related gene (ECRG4) which was first identified by screening for up- or down-regulated genes in oesophageal cancer. The product of ECRG4, whic...

ea0019p210 | Neuroendocrinology and behaviour | SFEBES2009

EGFR antagonists promote disinhibited retinal ganglion cell axon regeneration by a glial-dependent mechanism

Morrison K , Ahmed Z , Leadbeater W , Gonzalez AM , Berry M , Logan A

It was reported that the inhibition of central nervous system (CNS) axon growth is mediated by Ca2+-dependent phosphorylation of epidermal growth factor receptor (pEGFR) and that local administration of small molecule EGFR antagonists to optic nerve lesions promoted retinal ganglion cell (RGC) axon regeneration (Koprivica et al. 2005). This result was attributed to suppression of EGFR kinase, which neutralised the axonal growth inhibitory potency of CNS myeli...

ea0007oc31 | Diabetes and metabolism | BES2004

Inducing pancreatic beta cell regeneration; interactions of transcription factors and peptide growth factors

Leadbeater W , Thyssen S , Strutt B , Chamson A , Arany E , Pin C , Logan A , Hill D

Pancreatic islet cell transplantation is proven to restore functional beta cell mass to achieve normoglycemia in diabetics, but is limited by low availability of human cadaveric donor tissue. A strategy to build capacity is to use stem cells (SCs), and induce their expansion and differentiation into functional islets in vitro. Islet cell neogenesis has been linked to transient and sequential expression of specific transcription factors (TFs) and the actions of endogenou...

ea0019p371 | Thyroid | SFEBES2009

Enlargement of the thyroid gland in a heterozygous PBF knock-in transgenic mouse model

Read M , Fong J , Lewy G , Smith V , Turnell A , Watkins R , Seed R , Stewart S , Warfield A , Leadbeater W , Kim D , Watkinson J , Franklyn J , Boelaert K , McCabe C

PTTG binding factor (PBF) is a poorly characterised 22 kDa protein that is implicated in the aetiology of pituitary and thyroid tumours. Our recent investigations have attempted to discern the function of PBF in vitro. In particular, we reported that PBF can inhibit the activity of the sodium iodide symporter (NIS), which is responsible for iodide uptake into thyroid cells. However, little is known about the precise role of PBF in vivo. We have now generated a mu...