Searchable abstracts of presentations at key conferences in endocrinology

ea0081p714 | Reproductive and Developmental Endocrinology | ECE2022

Serum concentrations of 17-hydroxyprogesterone and dehydroepiandrosterone sulfate in women with polycystic ovary syndrome and their relation to the parameters of glucose metabolism

Stogowska Ewa , Krentowska Anna , Adamska Agnieszka , Lebkowska Agnieszka , Kowalska Irina

Introduction: Polycystic ovary syndrome (PCOS) is characterized by menstrual disorders, hyperandrogenism and polycystic ovaries on ultrasonography. This hormonal disorder is also strongly associated with insulin resistance. The diagnosis of PCOS can be established after the exclusion of other causes of mentioned symptoms, such as non-classic congenital adrenal hyperplasia (NCAH). To date, several studies suggest the increased serum concentration of 17-hydroxyprogesterone (17-O...

ea0049ep1104 | Female Reproduction | ECE2017

Serum concentrations of betatrophin and its association with indirect indices of insulin resistance and beta cell function in women with polycystic ovary syndrome

Adamska Agnieszka , Lebkowska Agnieszka , Jacewicz Malgorzata , Krentowska Anna , Hryniewicka Justyna , Wolczynski Slawomir , Gorska Maria , Kowalska Irina

The accumulated data underline the role of betatrophin in glucose homeostasis. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and high risk of developing prediabetes and diabetes. The aim of our study was to investigate the relationship of serum betatrophin concentrations with indirect indices of insulin resistance and insulin secretion in women with PCOS, comparing to the control group. The study group comprised 43 women with PCOS and 16 controls matc...

ea0070aep797 | Reproductive and Developmental Endocrinology | ECE2020

Ovarian reserve and serum concentration of thyroid peroxidase antibodies in euthyroid women with different polycystic ovary syndrome phenotypes

Adamska Agnieszka , Lebkowska Agnieszka , Krentowska Anna , Pliszka Justyna , Adamski Marcin , Leśniewska Monika , Kowalska Irina

Objective: It has been shown that women with PCOS as well as with autoimmune thyroiditis (AIT), are characterized by increased incidence of infertility. Serum anti-Müllerian hormone (AMH), which reflects ovarian reserve, is elevated in PCOS women and is decreased in women with AIT. The Rotterdam criteria recognize four clinical PCOS phenotypes,i.e.,phenotype Acharacterized by clinical and/or biochemical hyperandrogenism (HA), menstrual dysfunction (oligo/amenorrhea) (Olig...

ea0020p500 | Obesity and Metabolism | ECE2009

Normal metabolic flexibility despite insulin resistance in lean and obese women with polycystic ovary syndrome

Straczkowski Marek , Kowalska Irina , Adamska Agnieszka , Karczewska-Kupczewska Monika , Nikolajuk Agnieszka , Lebkowska Agnieszka , Gorska Maria

Polycystic ovary syndrome (PCOS) is heterogeneous disorder, where insulin resistance might be involved in the development of endocrine and metabolic abnormalities. Insulin resistance is associated with the so-called metabolic inflexibility i.e. an impaired switch from lipid to glucose in response to insulin. The aim of the present study was to estimate glucose and lipid oxidation, metabolic flexibility and non-oxidative glucose metabolism in lean and obese PCOS patients.<p...

ea0037gp.06.08 | Reproduction: Female and PCOS | ECE2015

Plasma brain derived neurotrophic factor is decreased in women with polycystic ovary syndrome and related to the markers of endothelial dysfunction

Kowalska Irina , Karczewska-Kupczewska Monika , Adamska Agnieszka , Nikolajuk Agnieszka , Lebkowska Agnieszka , Otziomek Elzbieta , Wolczynski Slawomir , Straczkowski Marek

Introduction: Brain derived neurotrophic factor (BDNF) is a neurotrophin which plays a role in neuronal growth and differentiation. Decreased level of BDNF is supposed to play a role in the pathogenesis of the neurodegenerative diseases. Recent data indicate that BDNF could be also involved in angiogenesis. Several lines of evidence support the role of BDNF in glucose metabolism. The decreased level of BDNF are observed in obesity and type 2 diabetes mellitus. Polycystic ovary...

ea0022p493 | Female reproduction | ECE2010

Inflammatory markers, adiponectin and metabolic characteristics in different phenotypes of polycystic ovary syndrome

Kowalska Irina , Karczewska-Kupczewska Monika , Adamska Agnieszka , Nikolajuk Agnieszka , Lebkowska Agnieszka , Wolczynski Slawomir , Gorska Maria , Straczkowski Marek

Polycystic ovary syndrome (PCOS) is heterogeneous disorder leading to infertility. The introduction of Rotterdam criteria creates different PCOS phenotypes, i.e. hyperandrogenic anovulatory with (A) and without (B) polycystic ovaries (PCO) morphology in ultrasonography (usg), hyperandrogenic ovulatory with PCO morphology in usg (C), non-hyperandrogenic anovulatory with PCO morphology in usg (D). In PCOS insulin resistance might be involved in the development of endocrine and m...

ea0022p690 | Obesity | ECE2010

Serum fibroblast growth factor 21 in human obesity: regulation by hyperinsulinemia and relationship with glucose and lipid oxidation

Straczkowski Marek , Karczewska-Kupczewska Monika , Adamska Agnieszka , Nikolajuk Agnieszka , Lebkowska Agnieszka , Otziomek Elzbieta , Gorska Maria , Kowalska Irina

Fibroblast growth factor 21 (FGF21) might increase glucose uptake in adipocytes and reduce plasma glucose and triglycerides in animal models of diabetes. The aim of the present study was to assess serum FGF21 concentration in lean and obese subjects, its regulation by hyperinsulinemia and relationship with insulin sensitivity and glucose and lipid oxidation. We examined 76 subjects with normal glucose tolerance, 36 lean (BMI <25 kg/m2) and 39 overweight or obese...

ea0049ep466 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Type B insulin resistance syndrome in a patient with connective tissue disease

Lebkowska Agnieszka , Krentowska Anna , Adamska Agnieszka , Piasecka Beata , Lipinska Danuta , Kowal-Bielecka Otylia , Semple Robert , Gorska Maria , Kowalska Irina

Introduction: Type B insulin resistance syndrome is an autoimmune disorder characterized by the production of autoantibodies against the insulin receptor. It leads to glucose metabolism disorders, extreme insulin resistance, hyperandrogenism and is associated with other features of autoimmunity.Case report: A 27-year-old man, with a 2-years history of psoriasis, was admitted to our Department because of loss of weight (20 kg in 1 year) and fatigue. He al...

ea0041gp183 | Reproduction &amp; Endocrine Disruption | ECE2016

Intima media thickness and brachial artery flow mediated dilatation in women with polycystic ovary syndrome and type 1 diabetes mellitus

Lebkowska Agnieszka , Adamska Agnieszka , Tolwinska Joanna , Jacewicz Malgorzata , Hryniewicka Justyna , Milewski Robert , Wolczynski Slawomir , Bossowski Artur , Gorska Maria , Kowalska Irina

Polycystic ovary syndrome (PCOS) and type 1 diabetes (T1DM) are accompanied by increased risk of atherosclerosis. A higher prevalence of PCOS in T1DM patients has been reported. Brachial artery flow-mediated dilatation (FMD) and intima media thickness of common carotid artery (IMT) are used to detect an early endothelial dysfunction.The aim of our study was to examine IMT and FMD in T1DM women with PCOS. We also estimated the relation of IMT and FMD to c...

ea0037gp.06.04 | Reproduction: Female and PCOS | ECE2015

Phenotypic characteristic of type 1 diabetic women with polycystic ovary syndrome

Lebkowska Agnieszka , Adamska Agnieszka , Karczewska-Kupczewska Monika , Nikolajuk Agnieszka , Otziomek Elzbieta , Milewski Robert , Wolczynski Slawomir , Gorska Maria , Kowalska Irina

Introduction: The prevalence of polycystic ovary syndrome (PCOS) is increased in women with type 1 diabetes (T1DM) in comparison to the general population. It has been suggested that exogenous insulin administered to T1DM women in supraphysiological doses could act as co-gonadotropin and lead to disturbances observed in PCOS.Aim: The aim of this study was to evaluate the phenotypic characteristic and differences between diabetic women with PCOS (T1DM+PCO...