Searchable abstracts of presentations at key conferences in endocrinology

ea0077p8 | Adrenal and Cardiovascular | SFEBES2021

Comparative steroid profiling in large animals

Morgan Ruth , Denham Scott , Lee Patricia , Homer Natalie

Large animals are increasingly used a models for endocrine research. Unlike rodents they are cortisol-dominant and thus more similar to humans. In this study we use two novel analytical methods to compare the steroid profile of pigs, sheep and humans; 1. Simultaneous quantification of primary glucocorticoids, glucocorticoid precursors and mineralocorticoids in plasma (>20 steroids); 2.Quantification of glucocorticoids metabolites (>10 ...

ea0077lb57 | Late Breaking | SFEBES2021

A Novel LC-MS/MS Method for the Simultaneous Detection of Multiple Steroids in Plasma and Tissue Lysates, used to verify Cell Autonomous Sex Identity in birds

Denham Scott , Betterton Victoria , Ioannidis Jason , Lee Patricia , Zhao Debiao , Simpson Joanna , Caughey Sarah , Dunn Ian , Clinton Mike , Wilson Peter , Homer Natalie

Cell autonomous sex identity (CASI) of birds is the concept that sex-steroids have little or no effect on the development of secondary sexual characteristics in birds, and that sexual dimorphisms are determined by the sex-chromosome content of cells in individual tissues. In avian species males have a ZZ sex chromosome, while females are ZW. Sexual dimorphisms in chickens, such as muscle mass, comb and wattle size and hackles and spur development are believed to be determined ...