Searchable abstracts of presentations at key conferences in endocrinology

ea0081oc10.1 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 3 | ECE2022

Single-cell molecular and functional mapping of POMC neurons in obesity: a multi-modal approach

Leon Stephane , Simon Vincent , Lee Thomas H , Clark Samantha , Dupuy Nathalie , Le Feuvre Yves , Fioramonti Xavier , Cota Daniela , Quarta Carmelo

The brain plays a crucial role in maintaining the body’s energy needs, a process involving the activity of a group of hypothalamic neurons that express the neuropeptidergic marker pro-opiomelanocortin (POMC). POMC neuronal dysfunction can cause obesity and its associated metabolic sequelae. However, this population of neurons is highly diverse at a molecular and functional level, and whether or not such heterogeneity is implicated in disease establishment or progression h...