Searchable abstracts of presentations at key conferences in endocrinology

ea0003s36 | Insulin Resistance and Type 2 Diabetes in Adolescents and Young Adults | BES2002

Management of adolescents and young adults with insulin resistance

Lee W

Childhood onset Type 2 diabetes mellitus is appearing in Asia. Sadly, the risk factors appear to be obesity, a sedentary lifestyle, and a family history of type 2 diabetes mellitus or gestational diabetes and IUGR. Comorbidities include abnormal lipid profiles, steatohepatitis, hypertension for age and obstructive sleep apnoeaModalities of treatment include diet, exercise, insulin, metformin, and sulphonylureas and more recently, the use of insulin sens...

ea0029p237 | Calcium & Vitamin D metabolism | ICEECE2012

The daily calcium intake is associated with sarcopenia in older, non-obese koreans: the fourth korea national health an nutrition examination surveys (KNHANES IV) 2009

Park C. , Rhee E. , Oh K. , Park S. , Park S. , Kim S. , Lee W. , Seo M.

Backgroud: The association with daily calcium intake and sarcopenia has not been well established.Objective: The objective was to assess the associate of daily calcium intake and sarcopenia.Methods: We analysed the fourth Korea National Health and Nutrition Examination Survey (KNHANES) in old adult (over 50 years), conducted in 2009. A total of 1964 non-obese (body mass index (BMI) <25 kg/m2) old adults (871 men and ...

ea0005oc14 | Cardiovascular Endocrinology | BES2003

A single nucleotide polymorphism in the p22phox gene affects arterial compliance

Drummond R , Brosnan M , Lee W , Kirk A , Pathi V , Hamilton C , Dominiczak A

Increased superoxide(SO) production reduces nitric oxide(NO) bioactivity and increases oxidative stress contributing to endothelial dysfunction in vascular disease. The gene coding for p22phox, a critical component of the NADH/NAD(P)H oxidase enzyme system which produces vascular SO, is CYBA. Among the allelic polymorphisms reported in CYBA is C242T which is associated with progression of coronary atherosclerosis. Radial applanation tonometry with pulse waveform analysis (PWA)...

ea0029p535 | Diabetes | ICEECE2012

The Association of the severity of nonalcoholic fatty liver disease with development of type 2 diabetes: A 4-year longitudinal study

Choi J. , Bae J. , Park S. , Rhee E. , Park C. , Oh K. , Park S. , Kim S. , Lee W.

Aims: Nonalcoholic fatty liver disease (NAFLD) is reported to contribute to the development of type 2 diabetes, but it is largely unknown whether such a relationship between NAFLD and incident diabetes relates to the severity of NAFLD or it is independent. We aimed to evaluate the association of the severity of NAFLD with development of type 2 diabetes in a retrospective cohort of Korean subjects.Methods: This study included 7,849 individuals without dia...

ea0029p594 | Diabetes | ICEECE2012

Proteomic identification of plasma biomarkers in type 1 diabetes mellitus: an implication of hemopexin overexpression in diabetes mellitus

Lee Y. , Chen C. , Chen Y. , Lu Y. , Lee W. , Lu C. , Chen Y. , Chou H. , Timms J. , Chan H.

Type 1 diabetes mellitus (T1DM) not only is congenital disease that known as insulin-dependent diabetes, often occurs in children and adolescents. Recent advances in quantitative proteomics including fluorescence two-dimensional differential gel electrophoresis (2D-DIGE) and matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) have offered opportunities to discover plasma proteins as biomarkers for tracking the progression and for underst...

ea0005oc10 | Cardiovascular Endocrinology | BES2003

Genomic analysis of congenic rat strains identifies a new candidate gene for human hypertension

McBride M , Carr F , Graham D , Anderson N , Clark J , Lee W , Charchar F , Brosnan M , Dominiczak A

Objective. The aims of our study were to utilise a combination of high fidelity phenotyping, microarray gene expression profiling and conserved synteny mapping between rodent and human genomes to identify genetic determinants underlying human hypertension.Methods. We used the stroke-prone spontaneously hypertensive rat (SHRSP) and a congenic strain (SP.WKYGla2c*) produced by introgressing a quantitative trait locus responsible for blood pressure regulation on rat chromosom...

ea0054is3 | (1) | NuclearReceptors2018

Nuclear receptors, transcriptional enhancers, and gene regulation

Franco Hector L , Murakami Shino , Hou Tim Y , Vasquez Yasmin M , Liu Ziying , Nagari Anusha , Malladi Venkat S , Nandu Tulip , Kraus W Lee

Transcriptional enhancers, which function as nucleation sites for the assembly of transcription-regulating complexes across the genome, drive cell type-specific patterns of gene expression that underlie the distinct biological properties of different cell types. Although many features of active enhancers (e.g., H3K4me1, H3K27ac, enrichment of p300/CBP and Mediator, and enhancer RNA production) have been defined by genomic assays, the roles of these features in ERĪ± enhance...