Searchable abstracts of presentations at key conferences in endocrinology

ea0029p594 | Diabetes | ICEECE2012

Proteomic identification of plasma biomarkers in type 1 diabetes mellitus: an implication of hemopexin overexpression in diabetes mellitus

Lee Y. , Chen C. , Chen Y. , Lu Y. , Lee W. , Lu C. , Chen Y. , Chou H. , Timms J. , Chan H.

Type 1 diabetes mellitus (T1DM) not only is congenital disease that known as insulin-dependent diabetes, often occurs in children and adolescents. Recent advances in quantitative proteomics including fluorescence two-dimensional differential gel electrophoresis (2D-DIGE) and matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) have offered opportunities to discover plasma proteins as biomarkers for tracking the progression and for underst...

ea0029p1158 | Nuclear receptors and Signal transduction | ICEECE2012

Hypoxia-induced estrogen receptor alpha activation is mediated by both the MAPK and PI3K phosphorylation pathways

Park J. , Lee Y.

The estrogen receptor (ER) plays an important role in breast cancer development and progression. Hypoxia was shown to modulate the level of ERα expression and induce ligand-independent transcriptional activation of ERα, which may be intimately associated with the biology of breast carcinomas. Given that phosphorylation affects the transcriptional activity and stabilization of ERα, we examined the changes in phosphorylation of ERα under hypoxic conditions. H...

ea0029p1226 | Obesity | ICEECE2012

Curcumin inhibits the upregulation of cathepsin L by palmitate in fat

Yoo J. , Lee Y. , Kim J. , Kang S. , Nam J. , Park J. , Ahn C. , Song Y. , Kim K.

Objective: Cathepsin L can control adipogenesis and relate to acute coronary syndrome. However, it is not clear whether cathepsin L can be affected by saturated fatty acid and decrease by curcumin. We examined the hypothesis that palmitate upregulates cathepsin L expression in adipose tissue and curcumin can be block that effect.Methods: 3T3-L1 cells were fully differentiated for 8 to 10 days and treated with palmitate, LPS, IL6, TNF-α, IL6 neutrali...

ea0029p279 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Gastrectomy for early gastric cancer is associated with decreased cardiovascular mortality in accordance with amelioration of metabolic abnormalities, visceral adiposity and atherosclerosis

Lee Y. , Han S. , Kim H. , Hyung W. , Lim J. , Lee K. , Lee H. Lee E. , Kang E. , Ahn C. , Cha B. , Lee H.

Objectives: We investigated cardiovascular and all-cause mortality in patients who underwent gastrectomies for early gastric cancer (EGC), and analyzed the changes in metabolic parameters in these patients after surgery.Background: Bariatric surgery, including gastric banding and gastric bypass, effectively induces weight loss and resolves cardiovascular comorbidities in obese patients.Methods: 2477 patients who underwent gastrecto...

ea0029p1800 | Thyroid cancer | ICEECE2012

High prevalence of BRAFV600E mutation in the papillary thyroid carcinomas in Korea by peptide nucleic acid clamp real-time PCR

Kim S. , Kim S. , Paik M. , Jeong D. , Jeong Y. , Lee J. , Whangbo Y. , Cho H. , Oh M. , Yang S. , Kim C.

Introduction: Activating somatic mutation of the BRAF gene (V600E) has been identified as the most common genetic event in papillary thyroid carcinoma (PTC) with a variable frequency (32–87%) in various races by different methods.In this study, we report the genetic analysis of BRAF mutation in a Korean cohort of 211 PTC by peptide nucleic acid clamp real-time PCR.Methods: PNA clamp real-time PCR was applied for BRAF analysis ...

ea0029p504 | Diabetes | ICEECE2012

Glycoalbumin is the best indicator for glycemic variability assessed by continuous glucose monitoring

Suh S. , Joung J. , Park S. , Cho Y. , Jin S. , Kim S. , Kim H. , Bae J. , Kim S. , Chung J. , Min Y. , Lee M. , Lee M. , Kim K. , Kim J.

Aims: We investigated the interrelationship between HbA1c, fructosamine, glycoalbumin (GA), 1,5-anhydroglucitol (1,5-AG) with glycemic variability data from continuous glucose monitoring system (CGMS).Methods: Seventy diabetic patients (mean age of 54 years including seven type 1 diabetes mellitus subjects) were enrolled, and all wore a CGMS for 72 hours. For the parameters of glucose excursion, mean glucose, standard deviation (SD) of glucose, the area ...

ea0029p685 | Diabetes | ICEECE2012

A Randomized controlled trial of the effect of internet based mentoring program for type 1 diabetes patients with inadequate glycemic control

Suh S. , Park S. , Cho Y. , Joung J. , Jin S. , Kim S. , Kim H. , Bae J. , Kim S. , Chung J. , Min Y. , Lee M. , Lee M. , Kim K. , Kim J.

Introduction: Widespread availability of internet makes it an attractive communication tool among patients and providers. However, the clinical benefit of telemedical support on diabetes care remains inconclusive. This study is to determine whether an internet based mentoring program can improve glycemic control in type 1 diabetes (T1DM) patients with inadequate glycemic control.Methods: Patients with T1DM on intensive insulin therapy and with HbA1c &#x2...

ea0029p1388 | Pituitary Clinical | ICEECE2012

Diabetes insipidus could be the initial sign of primary hypophysitis

Suh S. , Park S. , Joung J. , Cho Y. , Jin S. , Kim S. , Kim H. , Bae J. , Kim J. , Kim S. , Chung J. , Min Y. , Lee M. , Lee M. , Kim K.

Introduction: The natural history of primary hypophysitis is incompletely understood and best treatment remains controversial.Methods: We performed a retrospective study of 19 patients (mean age of 47 years, fifteen women and four men) who were diagnosed with primary hypophysitis in Samsung Medical Center in Seoul, Korea, from January 2001 to October 2011.Results: Two patients had recent pregnancy and underlying autoimmunity. Most ...