Endocrine Abstracts

Background: Sepsis is a life-threatening inflammatory condition and a leading cause of death in hospitals. It arises when a microbial infection triggers prolonged and uncontrolled systemic inflammation resulting in progressing organ dysfunction. Recent experimental data suggest a possible involvement of ferroptosis – an iron-dependent form of regulated necrosis – in sepsis-mediated damage of many vital organs. However, its role in adrenal gland dysfunction and/or dam...

Background: Sepsis is the primary cause of mortality in intensive care units. It is characterized by compromised function of several vital organs, including the adrenal glands. However, little is known about the mechanisms involved in this process. Recent experimental data demonstrated a potential role of iron overload and related iron-dependent, lipid peroxide driven form of regulated necrosis known as ferroptosis in sepsis-induced multiorgan damage. In a previous study, we d...