Searchable abstracts of presentations at key conferences in endocrinology

ea0049mte14 | (1) | ECE2017

Thyroid carcinoma: complicated cases

Leite Valeriano

Thyroid neoplasias show a wide range of biological behaviours from indolent to highly aggressive, invasive and metastatic cancers. The great majority of thyroid carcinomas are successfully treated with surgery, radioactive iodine and TSH suppressive therapy. However, a subset of tumors can behave aggressively, with distant metastasis and/or local invasion. These patients have a poor prognosis and a shorter survival, remaining a challenging task in treatment options. Cytotoxic ...

ea0041mte6 | (1) | ECE2016

MEN syndromes

Leite Valeriano

Multiple endocrine neoplasia (MEN) syndromes are classically defined as the occurrence of two or more endocrine tumours in a patient, and include two major forms, characterized by development of tumours within specific endocrine glands, referred to as type 1 (MEN1) and type 2 (MEN2). These disorders are due to mutations in the MEN1 gene in MEN1 (parathyroid, pituitary or pancreatic tumours), and in the RET gene in MEN2 (which comprises three types: MEN2A with...

ea0040l4 | Molecular Targeted Therapy in Medullary and Well-Differentiated Thyroid Carcinoma | ESEBEC2016

Molecular targeted therapy in medullary and well-differentiated thyroid carcinoma

Leite Valeriano

Differentiated thyroid cancer (DTC) of papillary (PTC) and follicular (FTC) types with invasive loco-regional or metastatic disease, poorly differentiated (PDTC) and anaplastic thyroid cancers (ATC), as well as the C-cell derived medullary thyroid cancers (MTC), represent the major cause of mortality amongst thyroid cancer patients. Because such patients are resistant to standard therapy, they may be excellent candidates for innovative adjuvant approaches such as molecular tar...

ea0028s12.2 | Medullary thyroid cancer | SFEBES2012

RAS mutations in sporadic MTC

Leite Valeriano

In a series of 66 sporadic medullary thyroid carcinomas (MTC) we looked for mutations in RET, RAS and BRAF protooncogenes and correlated mutational analysis with the clinicopathological data of the patients. We performed PCR amplification and sequencing analysis of exons 5, 8, 10–16 of RET, of the three mutational hotspots (codons 12, 13, and 61) of the H-, K-, and N-RAS genes, and of the mutational hotspot (codon 600) and exon 11 of the BRAF gene. Somatic RET mutations w...

ea0084op-10-50 | Oral Session 10: Young Investigators / Clinical and Translational | ETA2022

Outcomes of lenvatinib therapy in poorly differentiated thyroid carcinoma

Roque Joao , Silva Tiago , Leite Valeriano

Introduction and objectives: Poorly differentiated thyroid carcinoma (PDTC) is a rare but aggressive thyroid tumor. PDTC frequently presents in advanced stages and conventional treatments are usually less effective than in differentiated thyroid carcinoma (DTC). Lenvatinib is a multi-kinase inhibitor approved for the treatment of radioiodine-refractory DTC, with significant improvement in progression free survival. Despite the inclusion of a minority PDTC patients in SELECT tr...

ea0049ep1219 | Clinical case reports - Thyroid/Others | ECE2017

Struma ovarii – A report of thirteen cases

Donato Sara , Simoes Helder , Leite Valeriano

Introduction: Struma ovarii (SO) is a rare ovarian teratoma characterized by the presence of thyroid tissue in >50% of the tumour. Malignant transformation is rare and defined by the same histological criteria as for thyroid cancer. There is few data on the literature and treatment is controversial. The objective of this study was to describe the clinical, pathologic and treatment characteristics of women diagnosed with SO in our centre.Methods: Retr...

ea0075t05 | Thyroid | EYES2021

An unusual case of a solitary adrenal metastasis of thyroid carcinoma

Maciel Joana , Vilar Helena , Leite Valeriano

Backgroud: Distant metastases from papillary thyroid cancer (PTC) are infrequent and associated with poor prognosis. Adrenal metastatic lesions in this setting are rare, generally associated with lung and skeletal metastases. There have been few reported cases of isolated adrenal metastases from thyroid carcinoma. Here we report a patient with a PTC who developed a large and solitary adrenal metastasis.Case Presentation: A 68-year-old men was submitted i...

ea0081ep575 | Endocrine-Related Cancer | ECE2022

Somatostatin analogues in the treatment of metastatic paraganglioma

Roque Joao , Regala Catarina , Silva Tiago , Leite Valeriano

Introduction: Paraganglioma (PGL) is a neuroendocrine tumor derived from extra adrenal autonomic paraganglia with a germinal mutation rate of 30%. Metastatic paraganglioma (MPGL) can only be predicted after evidence of secondary lesions and it can occur in up to 50% of cases. Clinical course is remarkably variable, but 5-year overall survival is generally around 50%. Treatment options include surgical resection, chemotherapy, radiotherapy, and 123I-MIBG. Being a neu...

ea0065p158 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019

Palliative electrochemotherapy treatment in a patient with advanced thyroid papillary carcinoma with cutaneous metastases

Cavaco Daniela , Carvalhal Sara , Vicente Helena , Leite Valeriano

Advanced papillary thyroid carcinoma (PTC) with cutaneous metastases may cause pain, ulceration and bleeding. Electrochemotherapy (ECT) is a minimally invasive oncologic treatment of tumours located in the skin and subcutaneous tissue. The electric pulses potentiates the toxicity of a cytostatic agent entering the tumour cell. It is highly effective especially to relieve pain and improve quality of life. The adverse events are local and transient. A case of progressive metasta...

ea0067gp1 | Poster Presentations | EYES2019

Papillary thyroid carcinoma and Graves disease: a case report

Pinheiro Sara Lomelino , Silva Tiago , Pereira Conceicao , Leite Valeriano

Background: Papillary thyroid cancer (PTC) is the most common type of thyroid carcinoma, but it rarely presents as an intrathoracic mass with concurrent hyperthyroidism due to Graves disease.Case presentation: A 73-year-old man presented with weight loss. Imaging by computed tomography (CT) documented a large mediastinal mass in the infrathyroidal space separate from the thyroid gland and pulmonary lesions suggestive of metastases. Neck ultrasound showed...