ea0014oc4.5 | Neuroendocriology basis | ECE2007
, Lejonklou Margareta Halin
, Skogseid Britt
Background: Homozygous inactivation of the MEN1 tumor suppressor gene frequently occurs in endocrine pancreatic tumors (EPT); however, a heterozygous germ line inactivation of the gene seems to lead to development of an increase amount of endocrine pancreatic cells. The Notch signaling cascade plays a vital role in sustaining the balance between cell proliferation, differentiation and apoptosis during pancreatic development. Whether Notch signaling is MEN1 depend...