Searchable abstracts of presentations at key conferences in endocrinology

ea0029mte24 | (1) | ICEECE2012

Approach to the management of the infertile couple

Lenzi A.

Infertility is defined by the World Health Organization (WHO) as the inability of a couple to achieve conception or bring a pregnancy to term after 1 year or more of regular, unprotected sexual intercourse. It remains a major clinical and social problem, affecting 13–15% of couples worldwide. Evaluation usually starts after 12 months, although it might be indicated earlier. The most common causes of infertility are divided into: male factor, related to sperm abnormalities...

ea0090p626 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Comparison of the Effects of a Ketogenic Diet and an Isocaloric Balanced Diet administered to Obese patients on Quality of Life and Sleep: a Randomized Clinical Trial

Gangitano Elena , Elena Spoltore Maria , Lenzi Andrea , Gnessi Lucio , Ray David

Introduction: The prevalence of obesity and metabolic disturbances is worryingly increasing worldwide, therefore the study of their pathophysiology is extremely important to find new strategies for their treatment. Obesity has an impact not only on the metabolism of the patients, but also profoundly influence their daily life, and potentially affect the quality of life and the quality of sleep. These latter are strictly related to the circadian rhythm of the individuals that, ...

ea0049gp168 | Obesity | ECE2017

Effects of short sleep duration on energy metabolism and energy balance in subjects with overweight and obesity

Poggiogalle Eleonora , Donini Lorenzo , Gnessi Lucio , Mariani Stefania , Calabretto Marianna , Luisi Federica , Lenzi Andrea , Lubrano Carla

Introduction: The chronic reduction of sleep duration is associated to an increased risk of weight gain, but mechanistic aspects remain to be fully elucidated. The aim of our study was to examine the relationship between short sleep duration and energy metabolism, fuel selection and energy balance in overweight and obesity. Methods: Inclusion criteria were: age 18–65 years, BMI ≥25 kg/m2. Use of any CNS medications, any psychiatric disorders and night shi...

ea0041ep957 | Steroid metabolism + action | ECE2016

Similarity and differences of maximal and sub-maximal endurance exercise in increase the serum testosterone and DHT concentrations in healthy males

Sgro Paolo , Sansone Massimiliano , Romanelli Francesco , Lenzi Andrea , Bianchini Serena , Luigi Luigi Di

Introduction: Physical exercise exerts several effects on endocrinological homeostasis and, in particular, sprint exercise elicits the largest testosterone response per unit of work, while in response to prolonged endurance exercise testosterone levels will typically decline. In contrast to a large amount of paper about the modification of testosterone during physical exercise few study evaluated how DHT was influenced by a single bout of aerobic exercise.<p class="abstext...

ea0059p010 | Adrenal and steroids | SFEBES2018

Exploring the utility of renin measurements in the routine management of salt-wasting congenital adrenal hyperplasia

Pofi Riccardo , Cannuccia Amalia , Lenzi Andrea , Isidori Andrea M , Tomlinson Jeremy W

The importance of measuring renin or plasma renin activity (PRA) and aldosterone in establishing mineralocorticoid deficiency is not in doubt. Once mineralocorticoid replacement therapy is initiated, guidance suggests that optimization of mineralocorticoid dose should be based upon measurements of blood pressure, renin (or PRA), and electrolytes. The aim of this study was to explore the relationship between renin and clinically important variables to determine whether measurem...

ea0070aep803 | Reproductive and Developmental Endocrinology | ECE2020

TU score: A new proposal for an ultrasound scoring system to predict testicular function

Carlomagno Francesco , Pozza Carlotta , Gianfrilli Daniele , Tenuta Marta , Sesti Franz , Mazzotta Paola , Lenzi Andrea , Isidori Andrea

Background: Testicular ultrasound (US) is routinely employed in the evaluation of reproductive and sexual function. However, its use for characteristics other than testicular volume is hampered by a lack of information on the prognostic value of its findings, that to date have only been incorporated in a score proposed by Lenz et al. in 1993.Objectives: We sought to explore whether testicular US examination can predict spermatogenesis and provid...

ea0029p831 | Endocrine tumours and neoplasia | ICEECE2012

Non pituitary effects of GnRH analogues in prostate cancer cells: revertion of maligant phenotype and synergism with bicalutamide and radiotherapy

Festuccia C. , Gravina G. , Marampon F. , Piccolella M. , Motta M. , Lenzi A. , Tobolini V. , Jannini E.

Background: Gonadotropin-releasing hormone (GnRH) receptor is a G protein-coupled receptor involved in the synthesis and release of pituitary gonadotropins. GnRH analogs constitute the most widely employed medical treatment for prostatic cancer. The predominant mechanism of action is presumed to be via the inhibition of gonadotropins and resultant decrease in androgen. Although pituitary and extra-pituitary GnRH-R transcripts appear identical, their functional characteristics ...

ea0026p694 | Diabetes complications | ECE2011

Type 2 diabetes mellitus and testosterone: a meta-analysis study

Corona Giovanni , Monami Matteo , Rastrelli Giulia , Aversa Antonio , Lenzi Andrea , Forti Gianni , Mannucci Edordo , Maggi Mario

Introduction: Type 2 diabetes mellitus (T2DM) is often associated with male hypogonadism. The role of testosterone replacement therapy (TRT) in T2DM has not been completely clarified. To systematically analyse the relationship between androgen levels and T2DM by reviewing and meta-analyzing available prospective and cross-sectional studies. In addition, a specific meta-analysis on the metabolic effects of TRT in available randomised clinical trials (RCTs) was also performed.</...

ea0020oc4.6 | Acromegaly/IGF1/Type 2 Diabetes | ECE2009

Cardiovascular effects of chronic Sildenafil treatment in men with type 2 diabetes

Isidori Andrea , Giannetta Elisa , Carbone Iacopo , Vizza Dario , Orano Susanna , Vingolo Enzo , Bonifacio Vincenzo , Lenzi Andrea

In type 2 diabetes (T2DM), cardiomiopathy is characterized by an impairment of diastolic performance resulting in ventricular hypertrophy and dilatation. Heart remodelling leads to an increase in its angle of torsion, measurable by innovative cine-magnetic resonance imaging (MRI). To evaluate the impact of phosphodiesterase 5 inhibitors (PDE5i) on cardiovascular performance in T2DM, we designed a randomized, placebo-controlled, double blind (subject/outcome assessor) study on ...

ea0020p48 | Adrenal | ECE2009

Cannabinoids and regulation of adipogenesis in differentiating 3t3-l1 preadipocytes

Isidori Andrea M , Lolli Francesca , Pierotti Silvia , Pozza Carlotta , Bonifacio Vincenzo , Gandini Loredana , Lenzi Andrea

Objective: Endocannabinoids (CBs) are novel lipid mediators that modulate appetitive behaviour and energy metabolism. The overactivation of the endocannabinoid system plays an important role in obesity. Endocannabinoids may regulate the lipid metabolism through their receptors (CB1 and CB2) in liver and adipose tissue. 11β-hydroxysteroid dehydrogenase (11β-HSD1) type 1 regulates the local availability of active glucocorticoid, potent inductors of adipogenic different...