Searchable abstracts of presentations at key conferences in endocrinology

ea0032p684 | Neuroendocrinology | ECE2013

Roles of kisspeptin partners, NKB and dynorphin, in the control of gonadotropin secretion: revisiting the KNDy paradigm

Ruiz-Pino Francisco , Garcia-Galiano David , Manfredi-Lozano Maria , Leon Silvia , Sanchez-Garrido Miguel A , Roa Juan , Pinilla Leonor , Navarro Victor , Tena-Sempere Manuel

KNDy neurons, which co-express kisspeptins, neurokinin B (NKB) and dynorphin (Dyn), play a key role in the tonic control of gonadotropin secretion by modulating the GnRH release. The assumed KNDy model proposes that NKB and Dyn (as stimulatory and inhibitory signals, respectively) auto-regulate the secretion of kisspeptins onto GnRH neurons. However, some aspects of this paradigm remain poorly defined. In this context, the aims of this work were to characterize i) the putative...

ea0037oc7.4 | Neuroendocrinology and pituitary-basic | ECE2015

Gonadotropin-inhibitory hormone signalling displays sexually dimorphic roles in the control of energy homeostasis: studies in the NPFF1 receptor null mouse

Leon Silvia , Vazquez Maria Jesus , Barroso Alexia , Garcia-Galiano David , Ruiz-Pino Francisco , Manfredi-Lozano Maria , Romero-Ruiz Antonio , Sanchez-Garrido Miguel A , Dieguez Carlos , Nogueiras Ruben , Roa Juan , Pinilla Leonor , Tena-Sempere Manuel

RF-amide-related peptide-3 (RFRP-3), the mammalian orthologue of the avian gonadotropin-inhibiting hormone (GnIH), has been proposed as major inhibitory signal for the reproductive axis, acting via the NPFF1 receptor (NPFF1R). In addition, RFRP-3 has been recently suggested to modulate feeding, with reported orexigenic actions; a function that might contribute to the integrative control of energy homeostasis and reproduction. However, characterisation of the metabolic effects ...

ea0037gp.13.04 | Diabetes and obesity – Translational cardiovascular and obesity | ECE2015

Metabolic and gonadotropic impact of sequential obesogenic insults in the female: influence of the loss of ovarian secretion

Sanchez-Garrido Miguel A , Ruiz-Pino Francisco , Manfredi-Lozano Maria , Leon Silvia , Heras Violeta , Castellano Juan M , Vazquez Maria Jesus , Roa Juan , Romero-Ruiz Antonio , Dieguez Carlos , Pinilla Leonor , Tena-Sempere Manuel

While female fertility is known to be sensitive to conditions of low body fuel reserves, the reproductive consequences of persistent energy excess remain ill defined. Yet, the pandemic proportions of obesity, and its potential impact on the gonadotropic axis, call for a better understanding of this phenomenon. Alike, the influence of ovarian hormones on the pathophysiology of obesity and its complications merits further investigation. In this work, we aimed to elucidate the me...