Searchable abstracts of presentations at key conferences in endocrinology

ea0065p353 | Reproductive Endocrinology and Biology | SFEBES2019

Differential expression in granulosa-lutein (GL) cells from polycystic ovaries of genes implicated in assembly and modification of extracellular matrix (ECM)

Hardy Kate , Hopkins Thomas , Lerner Avigdor , Green Orla , Franks Stephen

Introduction: Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder in women and polycystic ovaries are characterized by excess ovarian stroma that has implications for disordered follicle development in PCOS. The factors contributing to proliferation and increased density of stroma remain unclear but local overproduction of androgens may be involved.Aim: To examine differential expression of genes that regulate key proteins that comprise ...

ea0041oc10.4 | Reproduction & Endocrine Disruption | ECE2016

Impaired adipose function in PCOS – evidence that the primary abnormalities are in subcutaneous rather than visceral fat

Siemienowicz Katarzyna , Coukan Flavien , Lerner Avigdor , Franks Stephen , Rae Mick , Duncan Colin

Central obesity and increased visceral adipose tissue (VAT) are key factors contributing to metabolic dysfunction in PCOS. We therefore hypothesized that there would be alterations in the morphology and function of adipocytes from visceral fat depots. The female offspring of pregnant sheep treated biweekly with either 100 mg of testosterone propionate (TP) or vehicle control (C) from day 62–102 of gestation develop a clinically realistic PCOS-like condition. They develop ...